Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 51979..52501 Replicon plasmid pmcr-1
Accession NZ_CP047014
Organism Escherichia coli strain 19-5

Toxin (Protein)


Gene name relE Uniprot ID U9YLU1
Locus tag GQF95_RS25265 Protein ID WP_000638823.1
Coordinates 51979..52260 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y7J1
Locus tag GQF95_RS25270 Protein ID WP_000121741.1
Coordinates 52250..52501 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQF95_RS25230 (GQF95_25190) 48128..48448 - 321 WP_000362080.1 VirB3 family type IV secretion system protein -
GQF95_RS26125 48519..48809 - 291 WP_000865479.1 conjugal transfer protein -
GQF95_RS25240 (GQF95_25200) 48809..49393 - 585 WP_001177113.1 lytic transglycosylase domain-containing protein -
GQF95_RS25245 (GQF95_25205) 49414..49812 - 399 WP_072643816.1 hypothetical protein -
GQF95_RS25250 (GQF95_25210) 49931..50368 - 438 WP_000539665.1 type IV pilus biogenesis protein PilM -
GQF95_RS25255 (GQF95_25215) 50374..51609 - 1236 WP_015059538.1 TcpQ domain-containing protein -
GQF95_RS25260 (GQF95_25220) 51612..51911 - 300 WP_000835764.1 TrbM/KikA/MpfK family conjugal transfer protein -
GQF95_RS25265 (GQF95_25225) 51979..52260 - 282 WP_000638823.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQF95_RS25270 (GQF95_25230) 52250..52501 - 252 WP_000121741.1 hypothetical protein Antitoxin
GQF95_RS25275 (GQF95_25235) 52601..53236 - 636 WP_015059536.1 hypothetical protein -
GQF95_RS25280 (GQF95_25240) 53309..53596 - 288 WP_001032611.1 EexN family lipoprotein -
GQF95_RS25285 (GQF95_25245) 53609..53863 - 255 WP_001043555.1 EexN family lipoprotein -
GQF95_RS25290 (GQF95_25250) 53865..54506 - 642 WP_001425343.1 type IV secretion system protein -
GQF95_RS25295 (GQF95_25255) 54512..55507 - 996 WP_001028543.1 type IV secretion system protein -
GQF95_RS25300 (GQF95_25260) 55511..55768 - 258 WP_000739144.1 hypothetical protein -
GQF95_RS25305 (GQF95_25265) 55765..56067 - 303 WP_001360345.1 hypothetical protein -
GQF95_RS25310 56048..56305 - 258 WP_001542015.1 hypothetical protein -
GQF95_RS25315 (GQF95_25270) 56338..56784 - 447 WP_001243165.1 hypothetical protein -
GQF95_RS25320 56795..56965 - 171 WP_000550720.1 hypothetical protein -
GQF95_RS25325 (GQF95_25275) 56969..57412 - 444 WP_000964330.1 NfeD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid mcr-1.1 - 1..60734 60734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10945.79 Da        Isoelectric Point: 10.4997

>T145330 WP_000638823.1 NZ_CP047014:c52260-51979 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR

Download         Length: 282 bp

>T145330 NZ_CP062358:2293384-2293491 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9223.38 Da        Isoelectric Point: 3.9823

>AT145330 WP_000121741.1 NZ_CP047014:c52501-52250 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL

Download         Length: 252 bp

>AT145330 NZ_CP062358:c2293568-2293508 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YLU1

Antitoxin

Source ID Structure
AlphaFold DB U9Y7J1

References