Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 2139..2740 Replicon plasmid ptetA
Accession NZ_CP047013
Organism Escherichia coli strain 19-5

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag GQF95_RS24430 Protein ID WP_109157903.1
Coordinates 2360..2740 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag GQF95_RS24425 Protein ID WP_001190712.1
Coordinates 2139..2360 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQF95_RS24400 (GQF95_24375) 88..354 + 267 WP_023356287.1 hypothetical protein -
GQF95_RS24405 (GQF95_24380) 357..608 + 252 WP_053272003.1 DNA polymerase III subunit theta -
GQF95_RS24410 (GQF95_24385) 592..984 + 393 WP_226149551.1 hypothetical protein -
GQF95_RS24415 (GQF95_24390) 1084..1473 + 390 WP_089477325.1 S24 family peptidase -
GQF95_RS24420 (GQF95_24395) 1608..2030 + 423 WP_089477326.1 hypothetical protein -
GQF95_RS24425 (GQF95_24400) 2139..2360 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GQF95_RS24430 (GQF95_24405) 2360..2740 + 381 WP_109157903.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GQF95_RS26095 2745..2942 + 198 WP_109157902.1 PdcA protein -
GQF95_RS24435 (GQF95_24410) 2975..3736 - 762 WP_109553090.1 hypothetical protein -
GQF95_RS24440 (GQF95_24415) 3743..4405 - 663 WP_060877112.1 DUF2829 domain-containing protein -
GQF95_RS24445 (GQF95_24420) 4420..4914 - 495 WP_151317981.1 dUTP diphosphatase -
GQF95_RS24450 (GQF95_24425) 4911..5387 - 477 WP_089477327.1 hypothetical protein -
GQF95_RS24455 (GQF95_24430) 5384..5728 - 345 WP_226149552.1 hypothetical protein -
GQF95_RS24460 (GQF95_24435) 5802..6830 - 1029 WP_089477328.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93419 93419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.34 Da        Isoelectric Point: 5.6343

>T145327 WP_109157903.1 NZ_CP047013:2360-2740 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGTATGEISVSTVAATLRRLYGSAE

Download         Length: 381 bp

>T145327 NZ_CP062358:c174017-173922 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT145327 WP_001190712.1 NZ_CP047013:2139-2360 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT145327 NZ_CP062358:173837-173894 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References