Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelE-RHH |
| Location | 1986..2533 | Replicon | plasmid pCMY-2 |
| Accession | NZ_CP047012 | ||
| Organism | Escherichia coli strain 19-5 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | GQF95_RS23830 | Protein ID | WP_244442846.1 |
| Coordinates | 2255..2533 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | E1QMW3 |
| Locus tag | GQF95_RS23825 | Protein ID | WP_000079941.1 |
| Coordinates | 1986..2255 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GQF95_RS23815 (46) | 46..1077 | + | 1032 | WP_000907873.1 | plasmid replication initiator RepA | - |
| GQF95_RS23820 (1773) | 1773..1931 | + | 159 | WP_000841008.1 | hypothetical protein | - |
| GQF95_RS23825 (1986) | 1986..2255 | + | 270 | WP_000079941.1 | type II toxin-antitoxin system antitoxin YacA | Antitoxin |
| GQF95_RS23830 (2255) | 2255..2533 | + | 279 | WP_244442846.1 | type II toxin-antitoxin system toxin YacB | Toxin |
| GQF95_RS23835 (2573) | 2573..3421 | + | 849 | WP_001057991.1 | 3'-5' exonuclease | - |
| GQF95_RS23840 (3538) | 3538..4011 | + | 474 | WP_001334658.1 | hypothetical protein | - |
| GQF95_RS23845 (4488) | 4488..4754 | - | 267 | WP_000955263.1 | hypothetical protein | - |
| GQF95_RS23850 (4754) | 4754..5248 | - | 495 | WP_001459505.1 | hypothetical protein | - |
| GQF95_RS23855 (5304) | 5304..5906 | - | 603 | WP_000517695.1 | ProQ/FINO family protein | - |
| GQF95_RS23860 (6260) | 6260..7144 | + | 885 | Protein_9 | protein YagA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCMY-2 | - | 1..101644 | 101644 | |
| - | flank | IS/Tn | blaCMY-2 | - | 7327..10058 | 2731 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10761.43 Da Isoelectric Point: 9.7617
>T145321 WP_244442846.1 NZ_CP047012:2255-2533 [Escherichia coli]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
Download Length: 279 bp
>T145321 NZ_CP062356:2569207-2569311 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10252.58 Da Isoelectric Point: 7.2057
>AT145321 WP_000079941.1 NZ_CP047012:1986-2255 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK
Download Length: 270 bp
>AT145321 NZ_CP062356:c2569469-2569306 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|