Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1044981..1045599 Replicon chromosome
Accession NZ_CP047010
Organism Escherichia coli strain 19-5

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag GQF95_RS05165 Protein ID WP_001291435.1
Coordinates 1044981..1045199 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag GQF95_RS05170 Protein ID WP_000344800.1
Coordinates 1045225..1045599 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQF95_RS05130 (1040270) 1040270..1040842 + 573 WP_113402281.1 YbaY family lipoprotein -
GQF95_RS05135 (1040873) 1040873..1041184 - 312 WP_000409911.1 MGMT family protein -
GQF95_RS05145 (1041563) 1041563..1041916 + 354 WP_000878140.1 DUF1428 domain-containing protein -
GQF95_RS05150 (1041958) 1041958..1043508 - 1551 WP_063501968.1 cyclic-guanylate-specific phosphodiesterase PdeB -
GQF95_RS05155 (1043672) 1043672..1044142 - 471 WP_000136192.1 YlaC family protein -
GQF95_RS05160 (1044258) 1044258..1044809 - 552 WP_000102564.1 maltose O-acetyltransferase -
GQF95_RS05165 (1044981) 1044981..1045199 - 219 WP_001291435.1 HHA domain-containing protein Toxin
GQF95_RS05170 (1045225) 1045225..1045599 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
GQF95_RS05175 (1046145) 1046145..1049294 - 3150 WP_113402280.1 efflux RND transporter permease AcrB -
GQF95_RS05180 (1049317) 1049317..1050510 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T145292 WP_001291435.1 NZ_CP047010:c1045199-1044981 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T145292 NZ_CP062350:2654467-2654829 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT145292 WP_000344800.1 NZ_CP047010:c1045599-1045225 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT145292 NZ_CP062350:2654300-2654470 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References