Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 184293..185336 | Replicon | chromosome |
| Accession | NZ_CP047010 | ||
| Organism | Escherichia coli strain 19-5 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | A0A7Z8DXL5 |
| Locus tag | GQF95_RS00900 | Protein ID | WP_021563277.1 |
| Coordinates | 184788..185336 (+) | Length | 183 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A839B6W4 |
| Locus tag | GQF95_RS00895 | Protein ID | WP_000287252.1 |
| Coordinates | 184293..184766 (+) | Length | 158 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GQF95_RS00865 (179325) | 179325..179933 | + | 609 | WP_000646078.1 | transcriptional repressor LexA | - |
| GQF95_RS00870 (180006) | 180006..181331 | + | 1326 | WP_001326646.1 | MATE family efflux transporter DinF | - |
| GQF95_RS00875 (181447) | 181447..181656 | + | 210 | WP_001030593.1 | CsbD family protein | - |
| GQF95_RS00880 (181698) | 181698..182213 | - | 516 | WP_001295691.1 | zinc uptake transcriptional repressor Zur | - |
| GQF95_RS26175 (182531) | 182531..182782 | + | 252 | Protein_165 | DUF2713 domain-containing protein | - |
| GQF95_RS00885 (182777) | 182777..183523 | + | 747 | WP_001395163.1 | DUF2713 family protein | - |
| GQF95_RS00890 (183884) | 183884..183988 | + | 105 | Protein_167 | tRNA-dihydrouridine synthase | - |
| GQF95_RS00895 (184293) | 184293..184766 | + | 474 | WP_000287252.1 | DUF4065 domain-containing protein | Antitoxin |
| GQF95_RS00900 (184788) | 184788..185336 | + | 549 | WP_021563277.1 | hypothetical protein | Toxin |
| GQF95_RS00905 (185370) | 185370..185642 | - | 273 | WP_001093913.1 | pyocin activator PrtN family protein | - |
| GQF95_RS00910 (185679) | 185679..186251 | - | 573 | WP_001061343.1 | 3'-5' exonuclease | - |
| GQF95_RS00915 (186251) | 186251..187060 | - | 810 | WP_000206745.1 | hypothetical protein | - |
| GQF95_RS00920 (187060) | 187060..187422 | - | 363 | WP_021563278.1 | phage protein | - |
| GQF95_RS00925 (187413) | 187413..187949 | - | 537 | WP_000008210.1 | 5'-deoxynucleotidase | - |
| GQF95_RS00930 (188077) | 188077..188901 | - | 825 | WP_000081280.1 | DUF2303 family protein | - |
| GQF95_RS00935 (188967) | 188967..189329 | - | 363 | WP_000135680.1 | protein YfdP | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 179325..230121 | 50796 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 183 a.a. Molecular weight: 19952.40 Da Isoelectric Point: 4.5662
>T145287 WP_021563277.1 NZ_CP047010:184788-185336 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQVFKSAFEPSNHESDDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQVFKSAFEPSNHESDDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK
Download Length: 549 bp
>T145287 NZ_CP062350:2260964-2261230 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA
Antitoxin
Download Length: 158 a.a. Molecular weight: 17298.80 Da Isoelectric Point: 8.4143
>AT145287 WP_000287252.1 NZ_CP047010:184293-184766 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL
Download Length: 474 bp
>AT145287 NZ_CP062350:2260707-2260964 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Z8DXL5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A839B6W4 |