Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 41668..42269 | Replicon | plasmid pfosA3 |
| Accession | NZ_CP047005 | ||
| Organism | Escherichia coli strain J-8 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | GQF94_RS24500 | Protein ID | WP_033551393.1 |
| Coordinates | 41668..42048 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | GQF94_RS24505 | Protein ID | WP_001190712.1 |
| Coordinates | 42048..42269 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GQF94_RS24465 (GQF94_24420) | 37060..37269 | + | 210 | WP_000874156.1 | hypothetical protein | - |
| GQF94_RS24470 (GQF94_24425) | 37380..38231 | + | 852 | WP_000611664.1 | phage repressor protein C1 | - |
| GQF94_RS25500 | 38264..38596 | - | 333 | WP_224205061.1 | phage antirepressor KilAC domain-containing protein | - |
| GQF94_RS25505 | 38717..39067 | - | 351 | Protein_46 | ORF6N domain-containing protein | - |
| GQF94_RS25510 | 39376..39597 | - | 222 | WP_072019028.1 | host cell division inhibitor Icd-like protein | - |
| GQF94_RS25515 | 39616..39735 | - | 120 | WP_001376634.1 | ash family protein | - |
| GQF94_RS24485 (GQF94_24440) | 39957..40289 | - | 333 | WP_033551395.1 | hypothetical protein | - |
| GQF94_RS24490 (GQF94_24445) | 40413..41456 | - | 1044 | WP_033551394.1 | DUF968 domain-containing protein | - |
| GQF94_RS24495 (GQF94_24450) | 41484..41663 | - | 180 | WP_000113018.1 | hypothetical protein | - |
| GQF94_RS24500 (GQF94_24455) | 41668..42048 | - | 381 | WP_033551393.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| GQF94_RS24505 (GQF94_24460) | 42048..42269 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GQF94_RS24510 (GQF94_24465) | 42452..42628 | + | 177 | Protein_54 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
| GQF94_RS24515 (GQF94_24470) | 42686..43092 | + | 407 | Protein_55 | IS1-like element IS1B family transposase | - |
| GQF94_RS24520 (GQF94_24475) | 43126..44640 | - | 1515 | Protein_56 | Tn3-like element TnAs1 family transposase | - |
| GQF94_RS24525 (GQF94_24480) | 44706..45410 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| GQF94_RS24530 (GQF94_24485) | 45465..45890 | + | 426 | Protein_58 | TetR/AcrR family transcriptional regulator | - |
| GQF94_RS24535 (GQF94_24490) | 45910..46698 | + | 789 | WP_014839978.1 | winged helix-turn-helix domain-containing protein | - |
| GQF94_RS24540 (GQF94_24495) | 46698..47216 | + | 519 | WP_014839979.1 | FidL-like protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | fosA3 / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR | - | 1..88744 | 88744 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13559.26 Da Isoelectric Point: 5.6277
>T145286 WP_033551393.1 NZ_CP047005:c42048-41668 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGGISVSSVADTLRRLYGSSE
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGGISVSSVADTLRRLYGSSE
Download Length: 381 bp
>T145286 NZ_CP062350:1168401-1168589 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT145286 WP_001190712.1 NZ_CP047005:c42269-42048 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT145286 NZ_CP062350:1168112-1168372 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|