Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4373136..4373754 Replicon chromosome
Accession NZ_CP047002
Organism Escherichia coli strain J-8

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag GQF94_RS20855 Protein ID WP_001291435.1
Coordinates 4373136..4373354 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E9TLB8
Locus tag GQF94_RS20860 Protein ID WP_000344794.1
Coordinates 4373380..4373754 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQF94_RS20820 (4368426) 4368426..4368998 + 573 WP_000779831.1 YbaY family lipoprotein -
GQF94_RS20825 (4369029) 4369029..4369340 - 312 WP_000409911.1 MGMT family protein -
GQF94_RS20835 (4369719) 4369719..4370072 + 354 WP_000878140.1 DUF1428 domain-containing protein -
GQF94_RS20840 (4370114) 4370114..4371664 - 1551 WP_001364591.1 cyclic-guanylate-specific phosphodiesterase PdeB -
GQF94_RS20845 (4371828) 4371828..4372298 - 471 WP_000136192.1 YlaC family protein -
GQF94_RS20850 (4372414) 4372414..4372965 - 552 WP_000102564.1 maltose O-acetyltransferase -
GQF94_RS20855 (4373136) 4373136..4373354 - 219 WP_001291435.1 HHA domain-containing protein Toxin
GQF94_RS20860 (4373380) 4373380..4373754 - 375 WP_000344794.1 Hha toxicity modulator TomB Antitoxin
GQF94_RS20865 (4374300) 4374300..4377449 - 3150 WP_001132470.1 efflux RND transporter permease AcrB -
GQF94_RS20870 (4377472) 4377472..4378665 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T145277 WP_001291435.1 NZ_CP047002:c4373354-4373136 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T145277 NZ_CP062348:c1872897-1872688 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14527.36 Da        Isoelectric Point: 4.9284

>AT145277 WP_000344794.1 NZ_CP047002:c4373754-4373380 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGRVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT145277 NZ_CP062348:c1873202-1872909 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGGGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References