Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3010688..3011489 Replicon chromosome
Accession NZ_CP047002
Organism Escherichia coli strain J-8

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag GQF94_RS14495 Protein ID WP_001094437.1
Coordinates 3011112..3011489 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2S1XZS0
Locus tag GQF94_RS14490 Protein ID WP_072645736.1
Coordinates 3010688..3011065 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQF94_RS14465 (3007803) 3007803..3007998 + 196 Protein_2858 DUF905 family protein -
GQF94_RS14470 (3008116) 3008116..3008934 + 819 WP_072645737.1 DUF932 domain-containing protein -
GQF94_RS14475 (3009276) 3009276..3009749 + 474 WP_000855064.1 antirestriction protein -
GQF94_RS14480 (3009765) 3009765..3010241 + 477 WP_001186775.1 RadC family protein -
GQF94_RS14485 (3010304) 3010304..3010525 + 222 WP_000692345.1 DUF987 domain-containing protein -
GQF94_RS14490 (3010688) 3010688..3011065 + 378 WP_072645736.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GQF94_RS14495 (3011112) 3011112..3011489 + 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
GQF94_RS14500 (3011486) 3011486..3011974 + 489 WP_000761715.1 DUF5983 family protein -
GQF94_RS14505 (3011994) 3011994..3012191 + 198 WP_000772032.1 DUF957 domain-containing protein -
GQF94_RS14510 (3012276) 3012276..3013121 + 846 WP_001274561.1 DUF4942 domain-containing protein -
GQF94_RS14515 (3013356) 3013356..3013517 + 162 Protein_2868 RhuM family protein -
GQF94_RS14520 (3013914) 3013914..3015098 + 1185 WP_001172876.1 sugar efflux transporter -
GQF94_RS14525 (3015209) 3015209..3016132 + 924 WP_000535960.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T145271 WP_001094437.1 NZ_CP047002:3011112-3011489 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T145271 NZ_CP062346:2781258-2781584 [Staphylococcus aureus]
ATGGATTGGGAAATTAAAAGTTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAATCATGG
TTGGCATGTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCGCAGAAATTAAAAATTAC
AGAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13787.61 Da        Isoelectric Point: 5.9541

>AT145271 WP_072645736.1 NZ_CP047002:3010688-3011065 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT145271 NZ_CP062346:2781046-2781255 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A2S1XZS0

References