Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3010688..3011489 Replicon chromosome
Accession NZ_CP047002
Organism Escherichia coli strain J-8

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag GQF94_RS14495 Protein ID WP_001094437.1
Coordinates 3011112..3011489 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2S1XZS0
Locus tag GQF94_RS14490 Protein ID WP_072645736.1
Coordinates 3010688..3011065 (+) Length 126 a.a.

Genomic Context

GQF94_RS14465GQF94_RS14470GQF94_RS14475GQF94_RS14480GQF94_RS14485GQF94_RS14490GQF94_RS14495GQF94_RS14500GQF94_RS14505GQF94_RS14510GQF94_RS14515GQF94_RS14520GQF94_RS14525
Location: 3007803..3007998 (196 bp)
Type: Others
Protein ID: Protein_2858
Location: 3008116..3008934 (819 bp)
Type: Others
Protein ID: WP_072645737.1
Location: 3009276..3009749 (474 bp)
Type: Others
Protein ID: WP_000855064.1
Location: 3009765..3010241 (477 bp)
Type: Others
Protein ID: WP_001186775.1
Location: 3010304..3010525 (222 bp)
Type: Others
Protein ID: WP_000692345.1
Location: 3010688..3011065 (378 bp)
Type: Antitoxin
Protein ID: WP_072645736.1
Location: 3011112..3011489 (378 bp)
Type: Toxin
Protein ID: WP_001094437.1
Location: 3011486..3011974 (489 bp)
Type: Others
Protein ID: WP_000761715.1
Location: 3011994..3012191 (198 bp)
Type: Others
Protein ID: WP_000772032.1
Location: 3012276..3013121 (846 bp)
Type: Others
Protein ID: WP_001274561.1
Location: 3013356..3013517 (162 bp)
Type: Others
Protein ID: Protein_2868
Location: 3013914..3015098 (1185 bp)
Type: Others
Protein ID: WP_001172876.1
Location: 3015209..3016132 (924 bp)
Type: Others
Protein ID: WP_000535960.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GQF94_RS14465 (3007803)3007803..3007998+196Protein_2858DUF905 family protein-
GQF94_RS14470 (3008116)3008116..3008934+819WP_072645737.1DUF932 domain-containing protein-
GQF94_RS14475 (3009276)3009276..3009749+474WP_000855064.1antirestriction protein-
GQF94_RS14480 (3009765)3009765..3010241+477WP_001186775.1RadC family protein-
GQF94_RS14485 (3010304)3010304..3010525+222WP_000692345.1DUF987 domain-containing protein-
GQF94_RS14490 (3010688)3010688..3011065+378WP_072645736.1type IV toxin-antitoxin system YeeU family antitoxinAntitoxin
GQF94_RS14495 (3011112)3011112..3011489+378WP_001094437.1TA system toxin CbtA family proteinToxin
GQF94_RS14500 (3011486)3011486..3011974+489WP_000761715.1DUF5983 family protein-
GQF94_RS14505 (3011994)3011994..3012191+198WP_000772032.1DUF957 domain-containing protein-
GQF94_RS14510 (3012276)3012276..3013121+846WP_001274561.1DUF4942 domain-containing protein-
GQF94_RS14515 (3013356)3013356..3013517+162Protein_2868RhuM family protein-
GQF94_RS14520 (3013914)3013914..3015098+1185WP_001172876.1sugar efflux transporter-
GQF94_RS14525 (3015209)3015209..3016132+924WP_000535960.1carboxylate/amino acid/amine transporter-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T145271 WP_001094437.1 NZ_CP047002:3011112-3011489 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T145271 NZ_CP062346:2781258-2781584 [Staphylococcus aureus]
ATGGATTGGGAAATTAAAAGTTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAATCATGG
TTGGCATGTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCGCAGAAATTAAAAATTAC
AGAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13787.61 Da        Isoelectric Point: 5.9541

>AT145271 WP_072645736.1 NZ_CP047002:3010688-3011065 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT145271 NZ_CP062346:2781046-2781255 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E0XS49

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2S1XZS0

References