Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 3955675..3956087 Replicon chromosome
Accession NZ_CP046973
Organism Microcystis aeruginosa FD4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GQR42_RS19755 Protein ID WP_199273353.1
Coordinates 3955675..3955878 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L7E1N4
Locus tag GQR42_RS19760 Protein ID WP_002739801.1
Coordinates 3955878..3956087 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQR42_RS19720 3951033..3951605 + 573 WP_158201275.1 manganese efflux pump MntP family protein -
GQR42_RS19725 3951594..3952322 - 729 WP_158201276.1 7-cyano-7-deazaguanine synthase QueC -
GQR42_RS19730 3952322..3952684 - 363 WP_158201277.1 aspartyl protease -
GQR42_RS19735 3952681..3952998 - 318 WP_158201278.1 hypothetical protein -
GQR42_RS19740 3953306..3953923 - 618 WP_158201279.1 7-carboxy-7-deazaguanine synthase QueE -
GQR42_RS19745 3953945..3954457 + 513 WP_158201280.1 Ycf51 family protein -
GQR42_RS19750 3954478..3955587 + 1110 WP_158201281.1 iron-containing alcohol dehydrogenase family protein -
GQR42_RS19755 3955675..3955878 + 204 WP_199273353.1 type II toxin-antitoxin system HicA family toxin Toxin
GQR42_RS19760 3955878..3956087 + 210 WP_002739801.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GQR42_RS19765 3956098..3956208 + 111 Protein_3931 type II toxin-antitoxin system HigB family toxin -
GQR42_RS19770 3956214..3956435 + 222 WP_158201282.1 hypothetical protein -
GQR42_RS19775 3956717..3956974 + 258 WP_158201283.1 hypothetical protein -
GQR42_RS19780 3956990..3958579 + 1590 WP_158201284.1 DUF3352 domain-containing protein -
GQR42_RS19785 3958553..3959800 - 1248 WP_158201285.1 bifunctional folylpolyglutamate synthase/dihydrofolate synthase -
GQR42_RS19790 3960187..3960912 - 726 WP_158201286.1 2-phosphosulfolactate phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7577.78 Da        Isoelectric Point: 10.7591

>T145250 WP_199273353.1 NZ_CP046973:3955675-3955878 [Microcystis aeruginosa FD4]
MVKKVKQVIKVLEADGWYLARTRGSHRQYKHPSKSGTVTVSGKSSVDVPIGTLKNIWRQAQIEEDKI

Download         Length: 204 bp

>T145250 NZ_CP062344:19314-19490 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7499.58 Da        Isoelectric Point: 3.8950

>AT145250 WP_002739801.1 NZ_CP046973:3955878-3956087 [Microcystis aeruginosa FD4]
MRYAVVIEKGENSYGAYVPDLPGCVAVAETLEEVKQLIAEAIIFHLEGLKEDGLTVPESLSICEYVDVA

Download         Length: 210 bp

>AT145250 NZ_CP062344:c19652-19478 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L7E1N4

References