Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 3955675..3956087 Replicon chromosome
Accession NZ_CP046973
Organism Microcystis aeruginosa FD4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GQR42_RS19755 Protein ID WP_199273353.1
Coordinates 3955675..3955878 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L7E1N4
Locus tag GQR42_RS19760 Protein ID WP_002739801.1
Coordinates 3955878..3956087 (+) Length 70 a.a.

Genomic Context

GQR42_RS19720GQR42_RS19745GQR42_RS19750GQR42_RS19755GQR42_RS19760GQR42_RS19765GQR42_RS19770GQR42_RS19775GQR42_RS19780GQR42_RS19725GQR42_RS19730GQR42_RS19735GQR42_RS19740GQR42_RS19785GQR42_RS19790
Location: 3951033..3951605 (573 bp)
Type: Others
Protein ID: WP_158201275.1
Location: 3953945..3954457 (513 bp)
Type: Others
Protein ID: WP_158201280.1
Location: 3954478..3955587 (1110 bp)
Type: Others
Protein ID: WP_158201281.1
Location: 3955675..3955878 (204 bp)
Type: Toxin
Protein ID: WP_199273353.1
Location: 3955878..3956087 (210 bp)
Type: Antitoxin
Protein ID: WP_002739801.1
Location: 3956098..3956208 (111 bp)
Type: Others
Protein ID: Protein_3931
Location: 3956214..3956435 (222 bp)
Type: Others
Protein ID: WP_158201282.1
Location: 3956717..3956974 (258 bp)
Type: Others
Protein ID: WP_158201283.1
Location: 3956990..3958579 (1590 bp)
Type: Others
Protein ID: WP_158201284.1
Location: 3951594..3952322 (729 bp)
Type: Others
Protein ID: WP_158201276.1
Location: 3952322..3952684 (363 bp)
Type: Others
Protein ID: WP_158201277.1
Location: 3952681..3952998 (318 bp)
Type: Others
Protein ID: WP_158201278.1
Location: 3953306..3953923 (618 bp)
Type: Others
Protein ID: WP_158201279.1
Location: 3958553..3959800 (1248 bp)
Type: Others
Protein ID: WP_158201285.1
Location: 3960187..3960912 (726 bp)
Type: Others
Protein ID: WP_158201286.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GQR42_RS197203951033..3951605+573WP_158201275.1manganese efflux pump MntP family protein-
GQR42_RS197253951594..3952322-729WP_158201276.17-cyano-7-deazaguanine synthase QueC-
GQR42_RS197303952322..3952684-363WP_158201277.1aspartyl protease-
GQR42_RS197353952681..3952998-318WP_158201278.1hypothetical protein-
GQR42_RS197403953306..3953923-618WP_158201279.17-carboxy-7-deazaguanine synthase QueE-
GQR42_RS197453953945..3954457+513WP_158201280.1Ycf51 family protein-
GQR42_RS197503954478..3955587+1110WP_158201281.1iron-containing alcohol dehydrogenase family protein-
GQR42_RS197553955675..3955878+204WP_199273353.1type II toxin-antitoxin system HicA family toxinToxin
GQR42_RS197603955878..3956087+210WP_002739801.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
GQR42_RS197653956098..3956208+111Protein_3931type II toxin-antitoxin system HigB family toxin-
GQR42_RS197703956214..3956435+222WP_158201282.1hypothetical protein-
GQR42_RS197753956717..3956974+258WP_158201283.1hypothetical protein-
GQR42_RS197803956990..3958579+1590WP_158201284.1DUF3352 domain-containing protein-
GQR42_RS197853958553..3959800-1248WP_158201285.1bifunctional folylpolyglutamate synthase/dihydrofolate synthase-
GQR42_RS197903960187..3960912-726WP_158201286.12-phosphosulfolactate phosphatase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7577.78 Da        Isoelectric Point: 10.7591

>T145250 WP_199273353.1 NZ_CP046973:3955675-3955878 [Microcystis aeruginosa FD4]
MVKKVKQVIKVLEADGWYLARTRGSHRQYKHPSKSGTVTVSGKSSVDVPIGTLKNIWRQAQIEEDKI

Download         Length: 204 bp

>T145250 NZ_CP062344:19314-19490 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7499.58 Da        Isoelectric Point: 3.8950

>AT145250 WP_002739801.1 NZ_CP046973:3955878-3956087 [Microcystis aeruginosa FD4]
MRYAVVIEKGENSYGAYVPDLPGCVAVAETLEEVKQLIAEAIIFHLEGLKEDGLTVPESLSICEYVDVA

Download         Length: 210 bp

>AT145250 NZ_CP062344:c19652-19478 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBL7E1N4

References