Detailed information of TA system TA145249

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/COG3657-dnstrm_HI1420
• Location: 3821045..3821636
• Replicon: chromosome
• Accession: NZ_CP046973
• Organism: Microcystis aeruginosa FD4

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: GQR42_RS19125
• Protein ID: WP_158201174.1
• Coordinates: 3821346..3821636 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GQR42_RS19120
• Protein ID: WP_158201173.1
• Coordinates: 3821045..3821335 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQR42_RS19105	3817195..3818079	+	885	WP_158201170.1	PEP-CTERM sorting domain-containing protein	-
GQR42_RS19110	3818279..3819310	+	1032	WP_158201171.1	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	-
GQR42_RS19115	3819504..3821048	+	1545	WP_158201172.1	gamma-glutamyltransferase	-
GQR42_RS19120	3821045..3821335	-	291	WP_158201173.1	putative addiction module antidote protein	Antitoxin
GQR42_RS19125	3821346..3821636	-	291	WP_158201174.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GQR42_RS19130	3821888..3823423	+	1536	WP_158201175.1	TolC family protein	-
GQR42_RS19135	3823609..3824400	-	792	WP_158201176.1	class I SAM-dependent methyltransferase	-
GQR42_RS19140	3824422..3826398	-	1977	WP_158201177.1	glycine oxidase ThiO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3764783..3858918	94135

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-95)

Antitoxin

• Uncharacterized protein HI1420 (3-93)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11113.67 Da
• Isoelectric Point: 9.7599

>T145249 WP_158201174.1 NZ_CP046973:c3821636-3821346 [Microcystis aeruginosa FD4]
MIEIRQTETYSEWFSDLRDHQAKARINIRIRRLSMGNPGDVKPVGRGVSELRVDYGPGYRVYFKQQGETLIILLTGGDKR
TQERDIKTALDLAQYL

Nucleotide

• Length: 291 bp

>T145249 NZ_CP062342:2704576-2704938 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10335.78 Da
• Isoelectric Point: 4.7164

>AT145249 WP_158201173.1 NZ_CP046973:c3821335-3821045 [Microcystis aeruginosa FD4]
MATIQTYPWDAADHLKTKEDIAAYLEAALEDGDPSLVVAALGDIARSQGMTHIARETGLGRESLYKSLSNQGNPEFATVL
KVLQALGLRLQVVPIT

Nucleotide

• Length: 291 bp

>AT145249 NZ_CP062342:2704409-2704579 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA