Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-DUF433
Location 3595165..3595925 Replicon chromosome
Accession NZ_CP046973
Organism Microcystis aeruginosa FD4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GQR42_RS17980 Protein ID WP_158200992.1
Coordinates 3595165..3595554 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GQR42_RS17985 Protein ID WP_158200993.1
Coordinates 3595677..3595925 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQR42_RS17965 3590892..3594419 + 3528 Protein_3570 class I SAM-dependent DNA methyltransferase -
GQR42_RS17970 3594542..3594730 + 189 WP_158200990.1 hypothetical protein -
GQR42_RS17975 3594863..3595168 + 306 WP_158200991.1 DUF2281 domain-containing protein -
GQR42_RS17980 3595165..3595554 + 390 WP_158200992.1 type II toxin-antitoxin system VapC family toxin Toxin
GQR42_RS17985 3595677..3595925 + 249 WP_158200993.1 DUF433 domain-containing protein Antitoxin
GQR42_RS17990 3595922..3596290 + 369 WP_158200994.1 DUF5615 family PIN-like protein -
GQR42_RS17995 3596530..3596853 + 324 WP_158202513.1 DUF433 domain-containing protein -
GQR42_RS18000 3596857..3597201 + 345 WP_158200995.1 DUF5615 family PIN-like protein -
GQR42_RS18005 3597213..3597461 + 249 WP_158200996.1 DUF433 domain-containing protein -
GQR42_RS18010 3597617..3598678 + 1062 WP_158200997.1 CIA30 family protein -
GQR42_RS18015 3598765..3599385 + 621 WP_158200998.1 CPP1-like family protein -
GQR42_RS18020 3599382..3600077 - 696 WP_158200999.1 HAD family hydrolase -
GQR42_RS18025 3600137..3600289 + 153 WP_158201000.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3589661..3590848 1187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-118)

Antitoxin

Protein of unknown function DUF433

(10-65)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14720.98 Da        Isoelectric Point: 4.5994

>T145248 WP_158200992.1 NZ_CP046973:3595165-3595554 [Microcystis aeruginosa FD4]
MKILLDTHFFLWFISGDQRLPTDMQAMIQDLDNEIYLSVVSTWEAIVKYQLGKLPLPESPATYFPRHCDRHQILNLDLDQ
ASVSQLANLPSLHRDPFDRMLICQALQNDIAIATVDGAVKAYPINLLEP

Download         Length: 390 bp

>T145248 NZ_CP062342:2684971-2685180 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9324.84 Da        Isoelectric Point: 4.5878

>AT145248 WP_158200993.1 NZ_CP046973:3595677-3595925 [Microcystis aeruginosa FD4]
MKTIAGLDRITFDPKIMAGQACIRGMRIPVSVIINLIANGLSTTEIIEDYPYLEPEDIQQALRYAAWLTQERVIFWQNTQ
AV

Download         Length: 249 bp

>AT145248 NZ_CP062342:2684666-2684959 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References