Detailed information of TA system TA145247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3182616..3183115
• Replicon: chromosome
• Accession: NZ_CP046973
• Organism: Microcystis aeruginosa FD4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GQR42_RS16040
• Protein ID: WP_158200717.1
• Coordinates: 3182616..3182873 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GQR42_RS16045
• Protein ID: WP_158200718.1
• Coordinates: 3182897..3183115 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQR42_RS16020	3177915..3179711	+	1797	WP_158200714.1	N-acetylmuramoyl-L-alanine amidase	-
GQR42_RS16025	3179988..3180176	+	189	WP_158200715.1	hypothetical protein	-
GQR42_RS16030	3180173..3182269	+	2097	WP_158200716.1	phosphate acetyltransferase	-
GQR42_RS16040	3182616..3182873	-	258	WP_158200717.1	type II toxin-antitoxin system VapC family toxin	Toxin
GQR42_RS16045	3182897..3183115	-	219	WP_158200718.1	DUF2281 domain-containing protein	Antitoxin
GQR42_RS16050	3183149..3183418	-	270	WP_158200719.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GQR42_RS16055	3183426..3183641	-	216	WP_158202494.1	hypothetical protein	-
GQR42_RS16060	3184542..3186051	+	1510	Protein_3195	hypothetical protein	-
GQR42_RS16065	3186481..3187047	+	567	WP_158200720.1	hypothetical protein	-
GQR42_RS16070	3187172..3187606	-	435	Protein_3197	esterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (5-85)

Antitoxin

• Domain of unknown function DUF2281 (7-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9701.30 Da
• Isoelectric Point: 4.9720

>T145247 WP_158200717.1 NZ_CP046973:c3182873-3182616 [Microcystis aeruginosa FD4]
MKSALIDTHVFIWLAEDDPILPVSLRDSLENTDNVFVSIASFWEISIKVKIGKLSLCSDFENLDTRFAATRFKLLPILFV
TFSHI

Nucleotide

• Length: 258 bp

>T145247 NZ_CP062342:2627710-2627814 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 7944.03 Da
• Isoelectric Point: 4.5026

>AT145247 WP_158200718.1 NZ_CP046973:c3183115-3182897 [Microcystis aeruginosa FD4]
MSIDSALKNIVENMPDALKTELLHYAEYLITKSDQTEEDKQAAKESVTVKRTLAGSMKGTFVLPLANDFDAP

Nucleotide

• Length: 219 bp

>AT145247 NZ_CP062342:c2627972-2627809 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT