Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2808933..2809714 Replicon chromosome
Accession NZ_CP046973
Organism Microcystis aeruginosa FD4

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag GQR42_RS14275 Protein ID WP_158200463.1
Coordinates 2809220..2809714 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag GQR42_RS14270 Protein ID WP_158200462.1
Coordinates 2808933..2809223 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQR42_RS14240 2804104..2804486 + 383 Protein_2836 type II toxin-antitoxin system VapC family toxin -
GQR42_RS14245 2804769..2805704 - 936 WP_079205656.1 IS110-like element ISMae40 family transposase -
GQR42_RS27810 2805686..2805853 + 168 WP_170863687.1 hypothetical protein -
GQR42_RS14250 2806077..2806934 + 858 WP_002732125.1 IS5-like element ISMae4 family transposase -
GQR42_RS14255 2807271..2807745 - 475 Protein_2840 hypothetical protein -
GQR42_RS14260 2807742..2808116 - 375 WP_158200460.1 nucleotidyltransferase domain-containing protein -
GQR42_RS14265 2808318..2808578 - 261 WP_158200461.1 hypothetical protein -
GQR42_RS14270 2808933..2809223 + 291 WP_158200462.1 DUF1778 domain-containing protein Antitoxin
GQR42_RS14275 2809220..2809714 + 495 WP_158200463.1 GNAT family N-acetyltransferase Toxin
GQR42_RS14280 2809864..2811086 + 1223 WP_158200464.1 ISAzo13 family transposase -
GQR42_RS27815 2811309..2811459 - 151 Protein_2846 ISNCY family transposase -
GQR42_RS14285 2811807..2813021 - 1215 WP_158200465.1 ABC transporter permease -
GQR42_RS14290 2813400..2813585 + 186 WP_158200466.1 hypothetical protein -
GQR42_RS14295 2813622..2814416 - 795 WP_158200467.1 tryptophan synthase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2804769..2811086 6317


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-142)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17673.37 Da        Isoelectric Point: 8.7034

>T145246 WP_158200463.1 NZ_CP046973:2809220-2809714 [Microcystis aeruginosa FD4]
MNLTPPEPLASYHSITDFSCGITSLDDWLKRRAYANQASGATRTFVTCVDNRVVGYYALASGAISIQSANGKFRRNMPNP
IPVVILARLAVDTSSQGQGLGRGLFRDGALRVVKAADTIGIRGIIVHAISEEAKNFYLALGFDVSPLEPMTLMITLNDLR
ACIA

Download         Length: 495 bp

>T145246 NZ_CP062342:2374613-2374879 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11130.76 Da        Isoelectric Point: 10.1412

>AT145246 WP_158200462.1 NZ_CP046973:2808933-2809223 [Microcystis aeruginosa FD4]
MSSKTKSKTPRNTLNLRIKREERNLIDMAAKVQGKNRTDFILEAARNAAEETLLERTIFWASPETYAEFIALLDAPPQPN
ERLRKTMQTIAPWEKE

Download         Length: 291 bp

>AT145246 NZ_CP062342:2374362-2374613 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References