Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 1373192..1373625 Replicon chromosome
Accession NZ_CP046973
Organism Microcystis aeruginosa FD4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GQR42_RS07010 Protein ID WP_158199416.1
Coordinates 1373192..1373416 (-) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GQR42_RS07015 Protein ID WP_149973724.1
Coordinates 1373413..1373625 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQR42_RS06985 1369057..1370142 - 1086 WP_158199412.1 alanine dehydrogenase -
GQR42_RS06990 1370373..1370675 - 303 WP_002761852.1 DUF3181 family protein -
GQR42_RS06995 1370668..1370922 - 255 WP_158199413.1 hypothetical protein -
GQR42_RS07000 1370999..1372867 - 1869 WP_158199414.1 cation:proton antiporter -
GQR42_RS07005 1372881..1373114 - 234 WP_158199415.1 hypothetical protein -
GQR42_RS07010 1373192..1373416 - 225 WP_158199416.1 type II toxin-antitoxin system HicA family toxin Toxin
GQR42_RS07015 1373413..1373625 - 213 WP_149973724.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GQR42_RS07020 1373757..1374570 - 814 Protein_1400 PEP-CTERM sorting domain-containing protein -
GQR42_RS07025 1374594..1374692 - 99 Protein_1401 proprotein convertase P-domain, (modular protein) -
GQR42_RS07030 1374874..1375053 + 180 WP_158199417.1 hypothetical protein -
GQR42_RS07035 1375551..1375796 - 246 WP_158199418.1 hypothetical protein -
GQR42_RS07040 1375801..1375968 - 168 WP_158199419.1 hypothetical protein -
GQR42_RS07045 1376467..1377615 + 1149 WP_158199420.1 Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha -
GQR42_RS07050 1377593..1377760 + 168 WP_158199421.1 hypothetical protein -
GQR42_RS07055 1377764..1378060 + 297 WP_002733247.1 NAD(P) transhydrogenase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(9-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8379.90 Da        Isoelectric Point: 11.2578

>T145244 WP_158199416.1 NZ_CP046973:c1373416-1373192 [Microcystis aeruginosa FD4]
MSELPPIAGRQVVKALGKIGYELDRQRGSHIILRQKAYPYRRITIPDHREVAKGTLRAIIRQAGLTVAEFKTLL

Download         Length: 225 bp

>T145244 NZ_CP062342:2318346-2318612 [Staphylococcus aureus]
ATGAGCAATTATACGGTTAAGATTAAAAATTCGGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAAAAGCC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACTGTAGATGATCGAAATAAAGAAGTATTAATA
TTATCGGCGTGGTCACATTATGATTAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7819.83 Da        Isoelectric Point: 3.6955

>AT145244 WP_149973724.1 NZ_CP046973:c1373625-1373413 [Microcystis aeruginosa FD4]
MKYRVLIEQDEDGIYVAEVPSLPGCISQGNTREELLANIQEAIALYLESLEAHNEPIPPPISEELVEVEL

Download         Length: 213 bp

>AT145244 NZ_CP062342:2318089-2318346 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGATGATTGGAAAAGTATACAAGAAACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGATAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References