Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4194848..4195467 Replicon chromosome
Accession NZ_CP046962
Organism Klebsiella pneumoniae subsp. pneumoniae strain WCHKP020130

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag CLQ86_RS20865 Protein ID WP_002892050.1
Coordinates 4195249..4195467 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag CLQ86_RS20860 Protein ID WP_002892066.1
Coordinates 4194848..4195222 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ86_RS20850 (CLQ86_20460) 4190000..4191193 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CLQ86_RS20855 (CLQ86_20465) 4191216..4194362 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
CLQ86_RS20860 (CLQ86_20470) 4194848..4195222 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
CLQ86_RS20865 (CLQ86_20475) 4195249..4195467 + 219 WP_002892050.1 HHA domain-containing protein Toxin
CLQ86_RS20870 (CLQ86_20480) 4195626..4196192 + 567 WP_002892030.1 maltose O-acetyltransferase -
CLQ86_RS20875 4196164..4196304 - 141 WP_004147370.1 hypothetical protein -
CLQ86_RS20880 (CLQ86_20485) 4196325..4196795 + 471 WP_002892026.1 YlaC family protein -
CLQ86_RS20885 (CLQ86_20490) 4196770..4198221 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
CLQ86_RS20890 (CLQ86_20495) 4198322..4199020 + 699 WP_002892021.1 GNAT family protein -
CLQ86_RS20895 (CLQ86_20500) 4199017..4199157 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
CLQ86_RS20900 (CLQ86_20505) 4199157..4199420 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T145234 WP_002892050.1 NZ_CP046962:4195249-4195467 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T145234 NZ_CP062340:2308317-2308583 [Staphylococcus aureus]
ATGAGCAATTATACGGTTAAGATTAAAAATTCGGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAAAAGCC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACTGTAGATGATCGAAATAAAGAAGTATTAATA
TTATCGGCGTGGTCACATTATGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT145234 WP_002892066.1 NZ_CP046962:4194848-4195222 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT145234 NZ_CP062340:2308060-2308317 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGATGATTGGAAAAGTATACAAGAAACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGATAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References