145212

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4887875..4888391 Replicon chromosome
Accession NZ_CP046957
Organism Klebsiella pneumoniae strain WCHKP015247

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag C6M24_RS24160 Protein ID WP_002886902.1
Coordinates 4887875..4888159 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag C6M24_RS24165 Protein ID WP_002886901.1
Coordinates 4888149..4888391 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6M24_RS24135 (C6M24_23710) 4883359..4883622 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
C6M24_RS24140 4883752..4883925 + 174 WP_002886906.1 hypothetical protein -
C6M24_RS24145 (C6M24_23715) 4883928..4884671 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
C6M24_RS24150 (C6M24_23720) 4885028..4887166 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
C6M24_RS24155 (C6M24_23725) 4887407..4887871 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
C6M24_RS24160 (C6M24_23730) 4887875..4888159 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6M24_RS24165 (C6M24_23735) 4888149..4888391 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C6M24_RS24170 (C6M24_23740) 4888469..4890379 - 1911 WP_004152270.1 PRD domain-containing protein -
C6M24_RS24175 (C6M24_23745) 4890402..4891556 - 1155 WP_002886900.1 lactonase family protein -
C6M24_RS24180 (C6M24_23750) 4891622..4892362 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T145212 WP_002886902.1 NZ_CP046957:c4888159-4887875 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T145212 NZ_CP062336:c1725938-1725576 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT145212 WP_002886901.1 NZ_CP046957:c4888391-4888149 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT145212 NZ_CP062336:c1726105-1725935 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References