Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4168080..4168699 Replicon chromosome
Accession NZ_CP046957
Organism Klebsiella pneumoniae strain WCHKP015247

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag C6M24_RS20690 Protein ID WP_002892050.1
Coordinates 4168481..4168699 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag C6M24_RS20685 Protein ID WP_002892066.1
Coordinates 4168080..4168454 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6M24_RS20675 (C6M24_20295) 4163232..4164425 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C6M24_RS20680 (C6M24_20300) 4164448..4167594 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
C6M24_RS20685 (C6M24_20305) 4168080..4168454 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
C6M24_RS20690 (C6M24_20310) 4168481..4168699 + 219 WP_002892050.1 HHA domain-containing protein Toxin
C6M24_RS20695 (C6M24_20315) 4168858..4169424 + 567 WP_002892030.1 maltose O-acetyltransferase -
C6M24_RS20700 4169396..4169536 - 141 WP_004147370.1 hypothetical protein -
C6M24_RS20705 (C6M24_20320) 4169557..4170027 + 471 WP_002892026.1 YlaC family protein -
C6M24_RS20710 (C6M24_20325) 4170002..4171453 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
C6M24_RS20715 (C6M24_20330) 4171554..4172252 + 699 WP_002892021.1 GNAT family protein -
C6M24_RS20720 (C6M24_20335) 4172249..4172389 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
C6M24_RS20725 (C6M24_20340) 4172389..4172652 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T145210 WP_002892050.1 NZ_CP046957:4168481-4168699 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T145210 NZ_CP062336:c522436-522248 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT145210 WP_002892066.1 NZ_CP046957:4168080-4168454 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT145210 NZ_CP062336:c522725-522465 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References