Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 880711..881365 Replicon chromosome
Accession NZ_CP046957
Organism Klebsiella pneumoniae strain WCHKP015247

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag C6M24_RS04460 Protein ID WP_004144731.1
Coordinates 880958..881365 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag C6M24_RS04455 Protein ID WP_002916312.1
Coordinates 880711..880977 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6M24_RS04430 (C6M24_04385) 875867..877300 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
C6M24_RS04435 (C6M24_04390) 877419..878147 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
C6M24_RS04440 (C6M24_04395) 878197..878508 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
C6M24_RS04445 (C6M24_04400) 878672..879331 + 660 WP_002916317.1 hemolysin III family protein -
C6M24_RS04450 (C6M24_04405) 879482..880465 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
C6M24_RS04455 (C6M24_04410) 880711..880977 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
C6M24_RS04460 (C6M24_04415) 880958..881365 + 408 WP_004144731.1 protein YgfX Toxin
C6M24_RS04465 (C6M24_04420) 881372..881893 - 522 WP_002916308.1 flavodoxin FldB -
C6M24_RS04470 (C6M24_04425) 881994..882890 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
C6M24_RS04475 (C6M24_04430) 882913..883626 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C6M24_RS04480 (C6M24_04435) 883632..885365 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T145200 WP_004144731.1 NZ_CP046957:880958-881365 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T145200 NZ_CP062334:163533-163685 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT145200 WP_002916312.1 NZ_CP046957:880711-880977 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT145200 NZ_CP062334:162909-163508 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References