Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4856971..4857487 Replicon chromosome
Accession NZ_CP046949
Organism Klebsiella pneumoniae strain BD_DM_914

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag GQY16_RS23475 Protein ID WP_004178374.1
Coordinates 4856971..4857255 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GQY16_RS23480 Protein ID WP_002886901.1
Coordinates 4857245..4857487 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQY16_RS23455 4852455..4852763 - 309 WP_022631369.1 PTS sugar transporter subunit IIB -
GQY16_RS29095 4852848..4853021 + 174 WP_032408826.1 hypothetical protein -
GQY16_RS23460 4853024..4853767 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GQY16_RS23465 4854124..4856262 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
GQY16_RS23470 4856503..4856967 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GQY16_RS23475 4856971..4857255 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQY16_RS23480 4857245..4857487 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GQY16_RS23485 4857565..4859475 - 1911 WP_004178373.1 BglG family transcription antiterminator -
GQY16_RS23490 4859498..4860652 - 1155 WP_004178372.1 lactonase family protein -
GQY16_RS23495 4860719..4861459 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T145193 WP_004178374.1 NZ_CP046949:c4857255-4856971 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T145193 NZ_CP062331:2378201-2378308 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT145193 WP_002886901.1 NZ_CP046949:c4857487-4857245 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT145193 NZ_CP062331:c2378385-2378325 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References