Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4109692..4110311 Replicon chromosome
Accession NZ_CP046949
Organism Klebsiella pneumoniae strain BD_DM_914

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GQY16_RS20035 Protein ID WP_002892050.1
Coordinates 4110093..4110311 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GQY16_RS20030 Protein ID WP_002892066.1
Coordinates 4109692..4110066 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQY16_RS20020 4104844..4106037 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GQY16_RS20025 4106060..4109206 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
GQY16_RS20030 4109692..4110066 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GQY16_RS20035 4110093..4110311 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GQY16_RS20040 4110470..4111036 + 567 WP_002892030.1 maltose O-acetyltransferase -
GQY16_RS29040 4111008..4111148 - 141 WP_004147370.1 hypothetical protein -
GQY16_RS20045 4111169..4111639 + 471 WP_002892026.1 YlaC family protein -
GQY16_RS20050 4111614..4113065 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
GQY16_RS20055 4113166..4113864 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
GQY16_RS20060 4113861..4114001 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GQY16_RS20065 4114001..4114264 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T145191 WP_002892050.1 NZ_CP046949:4110093-4110311 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T145191 NZ_CP062331:1226235-1226423 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT145191 WP_002892066.1 NZ_CP046949:4109692-4110066 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT145191 NZ_CP062331:1225946-1226206 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References