Detailed information of TA system TA145177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 2080045..2081558
• Replicon: chromosome
• Accession: NZ_CP046948
• Organism: Microbulbifer sp. SH-1

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: GNX18_RS08910
• Protein ID: WP_166217198.1
• Coordinates: 2080647..2081558 (+)
• Length: 304 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: GNX18_RS08905
• Protein ID: WP_166217195.1
• Coordinates: 2080045..2080650 (+)
• Length: 202 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GNX18_RS08890	2076031..2077461	-	1431	WP_166217186.1	MBL fold metallo-hydrolase	-
GNX18_RS08895	2077756..2078643	+	888	WP_166217189.1	hypothetical protein	-
GNX18_RS08900	2078686..2079864	+	1179	WP_166217192.1	hypothetical protein	-
GNX18_RS08905	2080045..2080650	+	606	WP_166217195.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
GNX18_RS08910	2080647..2081558	+	912	WP_166217198.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
GNX18_RS08915	2081957..2082844	+	888	WP_138233927.1	hypothetical protein	-
GNX18_RS08920	2082884..2084059	+	1176	WP_166217201.1	hypothetical protein	-
GNX18_RS08925	2084184..2084543	-	360	WP_205828102.1	hypothetical protein	-
GNX18_RS08930	2085510..2086307	-	798	WP_166217204.1	sulfotransferase family 2 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (56-284)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (8-55)

Sequences

Toxin

Protein

• Length: 304 a.a.
• Molecular weight: 33414.43 Da
• Isoelectric Point: 9.4485

>T145177 WP_166217198.1 NZ_CP046948:2080647-2081558 [Microbulbifer sp. SH-1]
VKNFSGENFRAKPKGARRKDAPNSNVAASVRARLLNAAKAQGVDFNQILVRYALERILYRLSQSKHADHFLLKGALLFTL
WYDMPHRATRDADLLGFGASDLESVAQTFRDIASVSVADGIMFDPTSVAAEEIRKDAGYTGARVLISSELANARCKTQID
IGFGDAVTPGPIDATYPVLLADQPAPRLRAYPVYTVIAEKLHAIAVLGMTNSRMKDYFDLSVLLERETLNTPLLAQALKA
TFERRGMALPEELPIGLKNEFAHDPSRQALWHAFIKKNELTLEPLPTVVDRLRATLGAALNQM

Nucleotide

• Length: 912 bp

>T145177 NZ_CP062329:18899-19075 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 202 a.a.
• Molecular weight: 22622.33 Da
• Isoelectric Point: 9.9203

>AT145177 WP_166217195.1 NZ_CP046948:2080045-2080650 [Microbulbifer sp. SH-1]
MPSDTHNQRVLDLARQKGLLRTSDLDAIDAPRVVLTRLTAAGLLNKVGRGLYRLPNYPGSEHEGLVTIATKVPQAVFCLL
SSLQFHELTTQLPRQIWIAMPRGSHVPRIDYPPIKMVQMSGEVYNAGIEEHLRDGVKLRVYGVAKTVVDCFKHRNKIGLD
VALEALKDARAQRKATADDLWRYAKICRVTNVMRPYLEAIE

Nucleotide

• Length: 606 bp

>AT145177 NZ_CP062329:c19237-19063 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG