Detailed information of TA system TA145176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1712046..1712587
• Replicon: chromosome
• Accession: NZ_CP046948
• Organism: Microbulbifer sp. SH-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GNX18_RS07445
• Protein ID: WP_166216651.1
• Coordinates: 1712285..1712587 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: GNX18_RS07440
• Protein ID: WP_166216647.1
• Coordinates: 1712046..1712288 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GNX18_RS07410	1707767..1708135	-	369	WP_138234945.1	nuclear transport factor 2 family protein	-
GNX18_RS07415	1708293..1708586	-	294	WP_166216633.1	hypothetical protein	-
GNX18_RS07420	1709054..1709593	-	540	WP_166216636.1	trypsin-like serine protease	-
GNX18_RS07425	1709655..1710623	+	969	WP_166216639.1	IS30 family transposase	-
GNX18_RS07430	1710638..1710985	-	348	WP_166216643.1	trypsin-like serine protease	-
GNX18_RS07435	1711276..1711971	+	696	WP_166220453.1	site-specific integrase	-
GNX18_RS07440	1712046..1712288	+	243	WP_166216647.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
GNX18_RS07445	1712285..1712587	+	303	WP_166216651.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GNX18_RS07450	1712725..1713057	-	333	WP_166216654.1	QacE family quaternary ammonium compound efflux SMR transporter	-
GNX18_RS07455	1713149..1713493	-	345	WP_166216657.1	alpha/beta hydrolase	-
GNX18_RS07460	1713621..1714082	-	462	WP_166216660.1	hypothetical protein	-
GNX18_RS07465	1715172..1715672	-	501	WP_138237304.1	hypothetical protein	-
GNX18_RS07470	1715901..1716800	+	900	WP_166214670.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1704558..1723957	19399

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11545.27 Da
• Isoelectric Point: 10.2534

>T145176 WP_166216651.1 NZ_CP046948:1712285-1712587 [Microbulbifer sp. SH-1]
MSSFKLSRKAKDDLRSIAKFTERRWGVAQRNVYIKKFDEAFHDLAESPFSGVSSENIKSGYRKIPHGAHIIFYKIGENDC
VEIIRILHQSMDVRSKLLST

Nucleotide

• Length: 303 bp

>T145176 NZ_CP062326:2651781-2652143 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8939.93 Da
• Isoelectric Point: 4.3690

>AT145176 WP_166216647.1 NZ_CP046948:1712046-1712288 [Microbulbifer sp. SH-1]
MAKNTSMTLGSHFDEFIAKEVASGRYGSASEVVRAGLRLLEDTETKLETLRTLLQEGEQSGFTDYTYESFIAELDEKKTP

Nucleotide

• Length: 243 bp

>AT145176 NZ_CP062326:2651614-2651784 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA