Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4811577..4812093 Replicon chromosome
Accession NZ_CP046939
Organism Klebsiella pneumoniae strain BD_DM_697

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag GQY17_RS23145 Protein ID WP_004178374.1
Coordinates 4811577..4811861 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GQY17_RS23150 Protein ID WP_002886901.1
Coordinates 4811851..4812093 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQY17_RS23125 4807061..4807369 - 309 WP_022631369.1 PTS sugar transporter subunit IIB -
GQY17_RS28760 4807454..4807627 + 174 WP_032408826.1 hypothetical protein -
GQY17_RS23130 4807630..4808373 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GQY17_RS23135 4808730..4810868 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
GQY17_RS23140 4811109..4811573 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GQY17_RS23145 4811577..4811861 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQY17_RS23150 4811851..4812093 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GQY17_RS23155 4812171..4814081 - 1911 WP_004178373.1 BglG family transcription antiterminator -
GQY17_RS23160 4814104..4815258 - 1155 WP_004178372.1 lactonase family protein -
GQY17_RS23165 4815325..4816065 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T145173 WP_004178374.1 NZ_CP046939:c4811861-4811577 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T145173 NZ_CP062326:c1168692-1168375 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT145173 WP_002886901.1 NZ_CP046939:c4812093-4811851 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT145173 NZ_CP062326:c1168904-1168695 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATAGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References