Detailed information of TA system TA145157

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 67813..68307
• Replicon: plasmid p_CNU_G2
• Accession: NZ_CP046920
• Organism: Streptococcus sp. CNU G2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPZ88_RS10155
• Protein ID: WP_157328647.1
• Coordinates: 67813..68085 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GPZ88_RS10160
• Protein ID: WP_157328649.1
• Coordinates: 68086..68307 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPZ88_RS10135	63101..64978	-	1878	WP_157328642.1	ATP-dependent Clp protease ATP-binding subunit	-
GPZ88_RS10140	64978..65337	-	360	WP_157328644.1	hypothetical protein	-
GPZ88_RS10145	66738..67316	-	579	WP_157328645.1	GTP pyrophosphokinase	-
GPZ88_RS10150	67382..67678	-	297	WP_166044397.1	hypothetical protein	-
GPZ88_RS10155	67813..68085	-	273	WP_157328647.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPZ88_RS10160	68086..68307	-	222	WP_157328649.1	translation repressor RelB	Antitoxin
GPZ88_RS10165	68384..68929	-	546	WP_166044399.1	hypothetical protein	-
GPZ88_RS10170	69132..69614	-	483	WP_157328653.1	hypothetical protein	-
GPZ88_RS10175	69681..69824	-	144	WP_157328655.1	hypothetical protein	-
GPZ88_RS10180	69859..70230	-	372	WP_157328658.1	hypothetical protein	-
GPZ88_RS10185	70261..70485	-	225	WP_157328660.1	hypothetical protein	-
GPZ88_RS10190	70482..70721	-	240	WP_157328662.1	hypothetical protein	-
GPZ88_RS10195	70805..71014	-	210	WP_157328664.1	hypothetical protein	-
GPZ88_RS10200	71033..71344	-	312	WP_157328665.1	hypothetical protein	-
GPZ88_RS10205	71413..71610	-	198	WP_157328667.1	hypothetical protein	-
GPZ88_RS10210	71647..72336	-	690	WP_157328669.1	DNA repair protein RadC	-
GPZ88_RS10215	72391..72726	-	336	WP_157328671.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..86459	86459

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10650.26 Da
• Isoelectric Point: 10.2622

>T145157 WP_157328647.1 NZ_CP046920:c68085-67813 [Streptococcus sp. CNU G2]
MYHVEYSKRAKKQIKKLDKSVQRLLFAWIDKNLEGCDNPRQHGKGLTANRANQWRYRIGNYRLICDIQDDKAVILALEFG
HRSTIYVRGE

Nucleotide

• Length: 273 bp

>T145157 NZ_CP062322:2626680-2626784 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8494.48 Da
• Isoelectric Point: 4.3690

>AT145157 WP_157328649.1 NZ_CP046920:c68307-68086 [Streptococcus sp. CNU G2]
MSTITVRLNQKEEELFKGYSELSGESISTLLKKALINNIEDELDYKVYQEAYQEYQKDSETISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT145157 NZ_CP062322:c2626942-2626779 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT