145155

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 65239..66156 Replicon chromosome
Accession NZ_CP046918
Organism Bacillus velezensis strain BA-26

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag GPY14_RS00385 Protein ID WP_094032372.1
Coordinates 65410..66156 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag GPY14_RS00380 Protein ID WP_003154807.1
Coordinates 65239..65409 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY14_RS00345 60462..62093 + 1632 WP_015417294.1 pyocin knob domain-containing protein -
GPY14_RS00350 62106..62477 + 372 WP_015417295.1 YomQ/XkdW protein, phage-like element PBSX -
GPY14_RS00355 62482..62679 + 198 WP_012117366.1 XkdX family protein -
GPY14_RS00360 62736..63497 + 762 WP_033575307.1 hypothetical protein -
GPY14_RS00365 63549..63812 + 264 WP_003154815.1 hemolysin XhlA family protein -
GPY14_RS00370 63826..64089 + 264 WP_003154813.1 phage holin -
GPY14_RS00375 64103..64981 + 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
GPY14_RS00380 65239..65409 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
GPY14_RS00385 65410..66156 - 747 WP_094032372.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
GPY14_RS00390 66261..67259 - 999 WP_020955696.1 inorganic phosphate transporter -
GPY14_RS00395 67272..67889 - 618 WP_003154804.1 DUF47 domain-containing protein -
GPY14_RS00400 68175..69491 - 1317 WP_007610842.1 amino acid permease -
GPY14_RS00405 69815..70765 + 951 WP_158185874.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.57 Da        Isoelectric Point: 4.7755

>T145155 WP_094032372.1 NZ_CP046918:c66156-65410 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQADKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

>T145155 NZ_CP062322:2348427-2348534 [Staphylococcus aureus]
ATCTTCAATTTATTAATTGACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCAAATTGGTTACGAAC
GCGCAGCAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT145155 WP_003154807.1 NZ_CP046918:c65409-65239 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp

>AT145155 NZ_CP062322:c2348611-2348551 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References