Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 467511..469267 Replicon chromosome
Accession NZ_CP046914
Organism Paraburkholderia acidisoli strain DHF22

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag FAZ98_RS16365 Protein ID WP_158952365.1
Coordinates 468368..469267 (-) Length 300 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag FAZ98_RS16360 Protein ID WP_158952364.1
Coordinates 467511..468371 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAZ98_RS16340 462730..464226 - 1497 WP_158952360.1 aldehyde dehydrogenase -
FAZ98_RS16345 464242..465069 - 828 WP_158952361.1 aspartate dehydrogenase -
FAZ98_RS16350 465062..466720 - 1659 WP_158952362.1 thiamine pyrophosphate-binding protein -
FAZ98_RS16355 466713..467510 - 798 WP_158952363.1 SDR family oxidoreductase -
FAZ98_RS16360 467511..468371 - 861 WP_158952364.1 IclR family transcriptional regulator Antitoxin
FAZ98_RS16365 468368..469267 - 900 WP_158952365.1 alpha/beta fold hydrolase Toxin
FAZ98_RS16370 469276..469815 - 540 WP_158952366.1 cupin domain-containing protein -
FAZ98_RS16375 469897..470667 - 771 WP_158952367.1 SDR family oxidoreductase -
FAZ98_RS16380 471070..472143 + 1074 WP_158952368.1 porin -
FAZ98_RS16385 472273..473235 - 963 WP_158952369.1 IclR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(46-280)

Antitoxin

Transcription regulator IclR, C-terminal

(145-267)


Sequences

Toxin        


Download         Length: 300 a.a.        Molecular weight: 31508.60 Da        Isoelectric Point: 6.3819

>T145153 WP_158952365.1 NZ_CP046914:c469267-468368 [Paraburkholderia acidisoli]
MRSTDLSFEARLEAFPAQCADVAPSRRIGYRDCGKAAAARAAALPLVLLHGIGSGAASWLQQLEALGTTRRVLAWDAPGY
GISTPVERASPHAADYAEALRGWLDALGIERCVLVGHSLGAIIAGSFAAAHPQRVAGVALLSPAGGYGAASEAVRVQKRD
ARLAMLAELGPQGLAAQRSANMLSTTASEAAREWVRWNMARIVPGGYAQATHLLANADLASDVARYRHEVTDDRKIGVAV
GTEDRITPPDACERIAQAANVPLQLIAGAGHAGYVEAPETYNTLIATFYETCEQQETQA

Download         Length: 900 bp

>T145153 NZ_CP062322:1197549-1197737 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31470.85 Da        Isoelectric Point: 6.3456

>AT145153 WP_158952364.1 NZ_CP046914:c468371-467511 [Paraburkholderia acidisoli]
MTLAPTGGVTEAAEDTSEVSYRVPGLERGLRILSEFSPREPVLGAPELSRRLGIPRTTVFRLLQTLESLGFLERADSERN
YRLGVAVLRLGFEYLSSLELTDLGLPLIEALRDSTGLSTHIVILDSRDVVFVAKAQSHAPVYSAVKVNVGTRLPAYATTH
GHVLMGDYTLDELHELYAGITLERFTKHTPGTVEELYERVRIDAERGFATSESSFEHGISVVSAPVRGDTGRIAAVVTTT
VPRAHIDTTLLESGLIEKVRETAHQLSLRLNYRPPAEHRFMKALGL

Download         Length: 861 bp

>AT145153 NZ_CP062322:1197260-1197520 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References