Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 462477..463114 Replicon chromosome
Accession NZ_CP046913
Organism Paraburkholderia acidisoli strain DHF22

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FAZ98_RS02040 Protein ID WP_158948297.1
Coordinates 462477..462875 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FAZ98_RS02045 Protein ID WP_158948299.1
Coordinates 462872..463114 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAZ98_RS02015 457762..458343 - 582 WP_158948287.1 Holliday junction branch migration protein RuvA -
FAZ98_RS02020 458503..459045 - 543 WP_158948289.1 crossover junction endodeoxyribonuclease RuvC -
FAZ98_RS02025 459198..460763 - 1566 WP_158948291.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
FAZ98_RS02030 460881..461114 - 234 WP_158948293.1 Fis family transcriptional regulator -
FAZ98_RS02035 461111..462190 - 1080 WP_158948295.1 tRNA dihydrouridine synthase DusB -
FAZ98_RS02040 462477..462875 - 399 WP_158948297.1 type II toxin-antitoxin system VapC family toxin Toxin
FAZ98_RS02045 462872..463114 - 243 WP_158948299.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FAZ98_RS02050 463207..464484 - 1278 WP_158948301.1 UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase -
FAZ98_RS02055 464531..466021 - 1491 WP_158948303.1 aminopeptidase P N-terminal domain-containing protein -
FAZ98_RS02060 466261..466872 + 612 WP_158948305.1 glutathione S-transferase N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14269.19 Da        Isoelectric Point: 5.9685

>T145150 WP_158948297.1 NZ_CP046913:c462875-462477 [Paraburkholderia acidisoli]
MKYLLDTNAVIAILKGDPAVLAKLHAHAPSDFGMPSVVAHELYYGAYKSQRAADNVARVAALQFELIPFDAEDAQHAGEI
RAQLAAAGTPIGPYDALIAGQARSRQLVLVTHNVREFERVAGLQFEDWQAAS

Download         Length: 399 bp

>T145150 NZ_CP062322:c167633-167538 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8893.10 Da        Isoelectric Point: 5.0334

>AT145150 WP_158948299.1 NZ_CP046913:c463114-462872 [Paraburkholderia acidisoli]
MDIARIFKHGGSQAVRLPKDFRFDTPEVRIRRHGAAVILEPVPQDWAWLAPLIGPLDDDFAAAAREAATAQDRPGLDVFE

Download         Length: 243 bp

>AT145150 NZ_CP062322:167453-167510 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References