Detailed information of TA system TA145149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 580901..582666
• Replicon: chromosome
• Accession: NZ_CP046912
• Organism: Paraburkholderia acidiphila strain 7Q-K02

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: FAZ97_RS32825
• Protein ID: WP_158762929.1
• Coordinates: 581764..582666 (-)
• Length: 301 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: FAZ97_RS32820
• Protein ID: WP_158762928.1
• Coordinates: 580901..581767 (-)
• Length: 289 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FAZ97_RS32800	576099..577592	-	1494	WP_158762924.1	aldehyde dehydrogenase	-
FAZ97_RS32805	577618..578445	-	828	WP_158762925.1	aspartate dehydrogenase	-
FAZ97_RS32810	578438..580096	-	1659	WP_158762926.1	thiamine pyrophosphate-binding protein	-
FAZ97_RS32815	580089..580904	-	816	WP_158762927.1	SDR family oxidoreductase	-
FAZ97_RS32820	580901..581767	-	867	WP_158762928.1	IclR family transcriptional regulator	Antitoxin
FAZ97_RS32825	581764..582666	-	903	WP_158762929.1	alpha/beta fold hydrolase	Toxin
FAZ97_RS32830	582697..583233	-	537	WP_158762930.1	cupin domain-containing protein	-
FAZ97_RS32835	583279..584055	-	777	WP_158763370.1	SDR family oxidoreductase	-
FAZ97_RS32840	584048..585133	-	1086	WP_158762931.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
FAZ97_RS32845	585169..585480	-	312	WP_158762932.1	hypothetical protein	-
FAZ97_RS32850	585482..585796	-	315	WP_158762933.1	non-heme iron oxygenase ferredoxin subunit	-
FAZ97_RS32855	586185..587306	+	1122	WP_199272209.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (50-278)

Antitoxin

• Transcription regulator IclR, N-terminal (19-67)

Sequences

Toxin

Protein

• Length: 301 a.a.
• Molecular weight: 31407.68 Da
• Isoelectric Point: 6.6933

>T145149 WP_158762929.1 NZ_CP046912:c582666-581764 [Paraburkholderia acidiphila]
MNDTIDTAASSAAPFETRLARFAQRAARVGEASVSYREAAGEGGNEALSLVLLHGIGSGAASWVQQFEALGGARRVLAWD
APGYGASTPVANASPLAADYARVLADWLDTLGIARCMLVGHSLGAIMAGAFAAAHPERVAGLLLISPAAGYGAADETVRA
EKRDTRLAMLAELGPQGLAQKRSANMLSPQADETARAWVRWNMARIVPHGYAQATHLLANADLAADLARCTGKVPMAVAV
GAQDTITPPEACERLAQIARAPFHVVPRAGHAGYIEQPLAYSTLIDFTLTHTFSTTELKA

Nucleotide

• Length: 903 bp

>T145149 NZ_CP062322:121312-121464 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 289 a.a.
• Molecular weight: 31817.25 Da
• Isoelectric Point: 7.4673

>AT145149 WP_158762928.1 NZ_CP046912:c581767-580901 [Paraburkholderia acidiphila]
MTPDVDEDRNDASYRVPGLERGLRILTEFSPREPVLDAPELSRRLGIPRTTVFRLLQTLESLGFLERADRDRNYRLGVAV
LRLGFEYLSSLELTDLGLPLIEALRDATGLTAHIVIRDGRDIVFVAKAQSHAPIFSSVKVNVGTRLPAHATTHGQVLMGD
LTLGELRALYPEPRLERFTPSTPETVEALFERIREDAERGYAVSESSFERGISVVSAPVRNDTGRIAAVVTTTIPRPGID
AQLLDGGLIEKVRHAANELSTRLNYRPQNRPQASSGKGTPYMKALGIK

Nucleotide

• Length: 867 bp

>AT145149 NZ_CP062322:120688-121287 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA