Detailed information of TA system TA145147

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 407654..408219
• Replicon: chromosome
• Accession: NZ_CP046910
• Organism: Paraburkholderia acidiphila strain 7Q-K02

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FAZ97_RS16290
• Protein ID: WP_158759495.1
• Coordinates: 407654..408025 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FAZ97_RS16295
• Protein ID: WP_158759496.1
• Coordinates: 408022..408219 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FAZ97_RS16270	402876..403943	+	1068	WP_158759491.1	AI-2E family transporter	-
FAZ97_RS16275	403980..404834	-	855	WP_158759492.1	esterase family protein	-
FAZ97_RS16280	404961..406058	-	1098	WP_158759493.1	OpgC domain-containing protein	-
FAZ97_RS16285	406770..407630	+	861	WP_158759494.1	peptidoglycan DD-metalloendopeptidase family protein	-
FAZ97_RS16290	407654..408025	-	372	WP_158759495.1	PIN domain-containing protein	Toxin
FAZ97_RS16295	408022..408219	-	198	WP_158759496.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FAZ97_RS16300	408399..409589	-	1191	WP_158759497.1	2-methylaconitate cis-trans isomerase PrpF	-
FAZ97_RS16305	409648..412245	-	2598	WP_158759498.1	Fe/S-dependent 2-methylisocitrate dehydratase AcnD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-113)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-44)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13458.58 Da
• Isoelectric Point: 4.8838

>T145147 WP_158759495.1 NZ_CP046910:c408025-407654 [Paraburkholderia acidiphila]
MILVDTSVWIDHFNAADPLLMGLLADERVLAHAYVIGEISLGSLRDREVVLGALRDLPAVPVATPEETFYLIEQAKLARR
GIGYVDTSLLASARLQPGVTIWTRDKRLEKVAGELGLGAQIEH

Nucleotide

• Length: 372 bp

>T145147 NZ_CP062320:c2193736-2193470 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7045.10 Da
• Isoelectric Point: 10.5916

>AT145147 WP_158759496.1 NZ_CP046910:c408219-408022 [Paraburkholderia acidiphila]
MRTTIALDDDLIAKAQAYTGLEEKTALVREALKALIQREAARRLANLGGSQPGIVAAPRRRTNAE

Nucleotide

• Length: 198 bp

>AT145147 NZ_CP062320:c2193993-2193736 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA