Detailed information of TA system TA145138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2123578..2124103
• Replicon: chromosome
• Accession: NZ_CP046907
• Organism: Streptomyces sp. SCUT-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GQS52_RS09205
• Protein ID: WP_182312927.1
• Coordinates: 2123840..2124103 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GQS52_RS09200
• Protein ID: WP_182312926.1
• Coordinates: 2123578..2123847 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQS52_RS09185	2119859..2120308	+	450	WP_182312923.1	helix-turn-helix transcriptional regulator	-
GQS52_RS09190	2120314..2120724	+	411	WP_182312924.1	VOC family protein	-
GQS52_RS09195	2120883..2123282	+	2400	WP_182312925.1	excinuclease ABC subunit UvrA	-
GQS52_RS09200	2123578..2123847	+	270	WP_182312926.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GQS52_RS09205	2123840..2124103	+	264	WP_182312927.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GQS52_RS09210	2124229..2125302	-	1074	WP_182312928.1	redox-regulated ATPase YchF	-
GQS52_RS09215	2125477..2126208	+	732	WP_182312929.1	hypothetical protein	-
GQS52_RS09220	2126288..2127055	-	768	WP_182312930.1	ROK family protein	-
GQS52_RS09225	2127136..2128125	-	990	WP_182316323.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-59)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10010.40 Da
• Isoelectric Point: 9.5559

>T145138 WP_182312927.1 NZ_CP046907:2123840-2124103 [Streptomyces sp. SCUT-3]
VSEYRTVFRPETQAELRKVPRDTALRILAKLTELESDPLGFGTTALVSRPDRRRLRVGDYRVIYTIDNGELVVWVVHVGH
RSNVYDA

Nucleotide

• Length: 264 bp

>T145138 NZ_CP062320:c536057-535869 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10191.70 Da
• Isoelectric Point: 4.9273

>AT145138 WP_182312926.1 NZ_CP046907:2123578-2123847 [Streptomyces sp. SCUT-3]
MTQPLPIESIRDVRAHLAEVVERADRDDMPTVITRRGKQVAAVVSIGVLRKYQEWEEREINRIIDERMAGPAPGIPIEEV
MRETLARSE

Nucleotide

• Length: 270 bp

>AT145138 NZ_CP062320:c536346-536086 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA