Detailed information of TA system TA145137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 2845728..2846293
• Replicon: chromosome
• Accession: NZ_CP046905
• Organism: Streptomyces sp. QHH-9511

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: GPZ77_RS12925
• Protein ID: WP_158987742.1
• Coordinates: 2845728..2846099 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: GPZ77_RS12930
• Protein ID: WP_158987744.1
• Coordinates: 2846096..2846293 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPZ77_RS12910	2841730..2842695	+	966	WP_158987736.1	helix-turn-helix domain-containing protein	-
GPZ77_RS12915	2842809..2843450	-	642	WP_158987738.1	helix-turn-helix domain-containing protein	-
GPZ77_RS12920	2843816..2845606	-	1791	WP_158987740.1	DEAD/DEAH box helicase	-
GPZ77_RS12925	2845728..2846099	-	372	WP_158987742.1	death-on-curing protein	Toxin
GPZ77_RS12930	2846096..2846293	-	198	WP_158987744.1	Arc family DNA-binding protein	Antitoxin
GPZ77_RS12935	2846322..2847809	-	1488	WP_158987746.1	MFS transporter	-
GPZ77_RS12945	2848140..2848523	+	384	WP_158987748.1	hypothetical protein	-
GPZ77_RS12950	2848700..2849608	+	909	WP_158987750.1	serine/threonine protein kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Arc-like DNA binding domain (5-43)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13591.17 Da
• Isoelectric Point: 4.5610

>T145137 WP_158987742.1 NZ_CP046905:c2846099-2845728 [Streptomyces sp. QHH-9511]
VTYHLTLPELLNLAERLGANEVRDYGLLDSALARPRSSVFGRDAYPDVWQKAAADMESPARNHGLVDGDKRITWYATWVF
PHLNGHPSDSGFDVDEAEIFELDVCQGALDVPKIAAQPPGFAR

Nucleotide

• Length: 372 bp

>T145137 NZ_CP062320:19734-19910 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7382.16 Da
• Isoelectric Point: 4.8377

>AT145137 WP_158987744.1 NZ_CP046905:c2846293-2846096 [Streptomyces sp. QHH-9511]
MAGLNVRFTEEELDALRERAEAEGRSMQSCAHDAVVRAVNEHSRLFDEAAEHVLKVSEEPNRRFA

Nucleotide

• Length: 198 bp

>AT145137 NZ_CP062320:c20072-19898 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGACTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG