Detailed information of TA system TA145135

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParST/RES-Xre
• Location: 3561292..3562073
• Replicon: chromosome
• Accession: NZ_CP046904
• Organism: Massilia flava strain DSM 26639

Toxin (Protein)

• Gene name: ParT
• Uniprot ID: -
• Locus tag: GO485_RS15030
• Protein ID: WP_145880346.1
• Coordinates: 3561609..3562073 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: ParS
• Uniprot ID: -
• Locus tag: GO485_RS15025
• Protein ID: WP_145880690.1
• Coordinates: 3561292..3561612 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GO485_RS15005	3556810..3557295	+	486	WP_145880339.1	DUF1857 family protein	-
GO485_RS15010	3557309..3558421	-	1113	WP_145880340.1	HD domain-containing protein	-
GO485_RS15015	3558568..3560013	-	1446	WP_145880342.1	dihydrolipoyl dehydrogenase	-
GO485_RS15020	3560101..3560988	+	888	WP_145880344.1	ArgP/LysG family DNA-binding transcriptional regulator	-
GO485_RS15025	3561292..3561612	+	321	WP_145880690.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
GO485_RS15030	3561609..3562073	+	465	WP_145880346.1	RES family NAD+ phosphorylase	Toxin
GO485_RS15035	3562086..3564107	-	2022	WP_145880348.1	primosomal protein N'	-
GO485_RS15040	3564709..3565788	-	1080	WP_145880350.1	uroporphyrinogen decarboxylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (4-137)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (3-36)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 16588.01 Da
• Isoelectric Point: 7.2782

>T145135 WP_145880346.1 NZ_CP046904:3561609-3562073 [Massilia flava]
MTAVWRIGIESPGYRANDLSSMGARLTGGRWNSEGVPMVYASASIALAMLETLVHLGGGDLPFNRFLVRIDIPEAQWNAR
SILEAPGGWDAIPAGITSRTAGDMWCAGARSLLLAVPSVVVPEEHNILINPRHADARLLNATTVRRLAYDPRTG

Nucleotide

• Length: 465 bp

>T145135 NZ_CP062318:2652006-2652368 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11311.02 Da
• Isoelectric Point: 6.3289

>AT145135 WP_145880690.1 NZ_CP046904:3561292-3561612 [Massilia flava]
VTKESLIGTLGLSRATLSRKARAGEKLARDESERVLGIEALIGQVQAMIDEAGNPEGFDAPRWMARWINAPLPALGGATP
ASYLDTVEGQKLIARLLAMMQSGTYA

Nucleotide

• Length: 321 bp

>AT145135 NZ_CP062318:2651839-2652009 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA