Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 5746..6334 Replicon plasmid pA1429b
Accession NZ_CP046900
Organism Acinetobacter baumannii strain A1429

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag GQO96_RS19995 Protein ID WP_000438827.1
Coordinates 5746..6033 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag GQO96_RS20000 Protein ID WP_001983304.1
Coordinates 6020..6334 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQO96_RS19965 908..1210 + 303 WP_032000438.1 hypothetical protein -
GQO96_RS19970 1622..2176 - 555 WP_104130815.1 plasmid replication DNA-binding protein -
GQO96_RS19975 2169..3122 - 954 WP_104130816.1 replication initiation protein RepM -
GQO96_RS19980 4420..4791 + 372 WP_005174618.1 hypothetical protein -
GQO96_RS19985 4794..4964 + 171 WP_002067611.1 hypothetical protein -
GQO96_RS19990 5014..5424 - 411 WP_000027956.1 hypothetical protein -
GQO96_RS19995 5746..6033 + 288 WP_000438827.1 BrnT family toxin Toxin
GQO96_RS20000 6020..6334 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
GQO96_RS20005 6462..8873 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
GQO96_RS20010 9178..9639 + 462 WP_000761346.1 DIP1984 family protein -
GQO96_RS20015 10838..11080 - 243 WP_032000428.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..19147 19147


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T145132 WP_000438827.1 NZ_CP046900:5746-6033 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T145132 NZ_CP062318:2321987-2322253 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT145132 WP_001983304.1 NZ_CP046900:6020-6334 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT145132 NZ_CP062318:2321736-2321987 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References