Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3062492..3063143 Replicon chromosome
Accession NZ_CP046898
Organism Acinetobacter baumannii strain A1429

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Q0RPK1
Locus tag GQO96_RS14720 Protein ID WP_000838147.1
Coordinates 3062961..3063143 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L9LVK3
Locus tag GQO96_RS14715 Protein ID WP_002053018.1
Coordinates 3062492..3062896 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQO96_RS14705 3057810..3061781 - 3972 WP_176673648.1 tape measure protein -
GQO96_RS14710 3061878..3062396 - 519 WP_005070358.1 DUF4468 domain-containing protein -
GQO96_RS14715 3062492..3062896 - 405 WP_002053018.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GQO96_RS14720 3062961..3063143 - 183 WP_000838147.1 type II toxin-antitoxin system HicA family toxin Toxin
GQO96_RS14725 3063475..3064008 - 534 WP_057691629.1 hypothetical protein -
GQO96_RS14730 3064056..3064985 - 930 WP_176673697.1 hypothetical protein -
GQO96_RS14735 3065094..3065306 - 213 WP_030423712.1 hypothetical protein -
GQO96_RS14740 3065308..3065751 - 444 WP_078195081.1 hypothetical protein -
GQO96_RS14745 3065708..3066076 - 369 WP_057691638.1 hypothetical protein -
GQO96_RS14750 3066048..3066455 - 408 WP_057691626.1 hypothetical protein -
GQO96_RS14755 3066562..3067275 - 714 WP_057691625.1 hypothetical protein -
GQO96_RS14760 3067313..3067681 - 369 WP_176673715.1 glutamate 5-kinase -
GQO96_RS14765 3067683..3068072 - 390 WP_000008501.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3034974..3101439 66465


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6682.88 Da        Isoelectric Point: 10.6602

>T145130 WP_000838147.1 NZ_CP046898:c3063143-3062961 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK

Download         Length: 183 bp

>T145130 NZ_CP062318:2265720-2265986 [Staphylococcus aureus]
ATGAGCAATTATACGGTTAAGATTAAAAATTCGGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAAAAGCC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACTGTAGATGATCGAAATAAAGAAGTATTAATA
TTATCGGCGTGGTCACATTATGATTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14660.69 Da        Isoelectric Point: 4.4289

>AT145130 WP_002053018.1 NZ_CP046898:c3062896-3062492 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT145130 NZ_CP062318:2265463-2265720 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGATGATTGGAAAAGTATACAAGAAACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGATAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q0RPK1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q0RVR6

References