145129

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1868229..1869865 Replicon chromosome
Accession NZ_CP046898
Organism Acinetobacter baumannii strain A1429

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GQO96_RS08895 Protein ID WP_032031323.1
Coordinates 1868229..1869560 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GQO96_RS08900 Protein ID WP_032031321.1
Coordinates 1869557..1869865 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQO96_RS08870 1863311..1864549 + 1239 WP_104130960.1 TolC family protein -
GQO96_RS08875 1864542..1865705 + 1164 WP_032031333.1 hypothetical protein -
GQO96_RS08880 1865832..1866803 + 972 WP_104130957.1 acid phosphatase -
GQO96_RS08885 1866815..1867459 + 645 WP_032031328.1 hypothetical protein -
GQO96_RS08890 1867494..1867934 - 441 WP_032031326.1 HD domain-containing protein -
GQO96_RS08895 1868229..1869560 + 1332 WP_032031323.1 type II toxin-antitoxin system HipA family toxin Toxin
GQO96_RS08900 1869557..1869865 + 309 WP_032031321.1 helix-turn-helix domain-containing protein Antitoxin
GQO96_RS08905 1870590..1871144 + 555 WP_032031319.1 TetR/AcrR family transcriptional regulator -
GQO96_RS08910 1871233..1871754 + 522 WP_032031318.1 hypothetical protein -
GQO96_RS08915 1871807..1872484 + 678 WP_032031317.1 HEPN domain-containing protein -
GQO96_RS08920 1872546..1873064 + 519 WP_032031314.1 GNAT family N-acetyltransferase -
GQO96_RS08925 1873429..1874097 + 669 WP_032031312.1 YkgJ family cysteine cluster protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51202.29 Da        Isoelectric Point: 4.9118

>T145129 WP_032031323.1 NZ_CP046898:1868229-1869560 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELNYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T145129 NZ_CP062318:1152490-1152678 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11614.54 Da        Isoelectric Point: 9.9701

>AT145129 WP_032031321.1 NZ_CP046898:1869557-1869865 [Acinetobacter baumannii]
MNIKNQAQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp

>AT145129 NZ_CP062318:1152201-1152461 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References