Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1573534..1574185 Replicon chromosome
Accession NZ_CP046898
Organism Acinetobacter baumannii strain A1429

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Q0RPK1
Locus tag GQO96_RS07495 Protein ID WP_000838147.1
Coordinates 1573534..1573716 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L9LVK3
Locus tag GQO96_RS07500 Protein ID WP_002053018.1
Coordinates 1573781..1574185 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQO96_RS07450 1568788..1569453 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
GQO96_RS07455 1569458..1569847 + 390 WP_000008492.1 hypothetical protein -
GQO96_RS07460 1569849..1570217 + 369 WP_002055673.1 hypothetical protein -
GQO96_RS07465 1570226..1570630 + 405 WP_176673646.1 hypothetical protein -
GQO96_RS07470 1570602..1570970 + 369 WP_030424006.1 hypothetical protein -
GQO96_RS07475 1570927..1571370 + 444 WP_176673647.1 hypothetical protein -
GQO96_RS07480 1571372..1571584 + 213 WP_001983388.1 hypothetical protein -
GQO96_RS07485 1571692..1572621 + 930 WP_000094301.1 hypothetical protein -
GQO96_RS07490 1572669..1573202 + 534 WP_057691629.1 hypothetical protein -
GQO96_RS07495 1573534..1573716 + 183 WP_000838147.1 type II toxin-antitoxin system HicA family toxin Toxin
GQO96_RS07500 1573781..1574185 + 405 WP_002053018.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GQO96_RS07505 1574281..1574799 + 519 WP_005070358.1 DUF4468 domain-containing protein -
GQO96_RS07510 1574896..1578867 + 3972 WP_176673648.1 tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1542144..1597025 54881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6682.88 Da        Isoelectric Point: 10.6602

>T145128 WP_000838147.1 NZ_CP046898:1573534-1573716 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK

Download         Length: 183 bp

>T145128 NZ_CP062318:c165173-165078 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14660.69 Da        Isoelectric Point: 4.4289

>AT145128 WP_002053018.1 NZ_CP046898:1573781-1574185 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT145128 NZ_CP062318:164993-165050 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q0RPK1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q0RVR6

References