Detailed information of TA system TA145127

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 447306..447947
• Replicon: chromosome
• Accession: NZ_CP046898
• Organism: Acinetobacter baumannii strain A1429

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A7Z1WP95
• Locus tag: GQO96_RS02165
• Protein ID: WP_002061280.1
• Coordinates: 447558..447947 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: GQO96_RS02160
• Protein ID: WP_011860336.1
• Coordinates: 447306..447551 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQO96_RS02140	442810..443817	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
GQO96_RS02145	443836..444213	+	378	WP_032030101.1	50S ribosomal protein L17	-
GQO96_RS02150	444395..445885	+	1491	WP_000415132.1	NAD(P)/FAD-dependent oxidoreductase	-
GQO96_RS02155	445934..447106	-	1173	WP_001190547.1	acyl-CoA dehydrogenase family protein	-
GQO96_RS02160	447306..447551	+	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
GQO96_RS02165	447558..447947	+	390	WP_002061280.1	hypothetical protein	Toxin
GQO96_RS02170	448717..449802	+	1086	WP_000049106.1	hypothetical protein	-
GQO96_RS02175	449880..450446	+	567	WP_000651536.1	rhombosortase	-
GQO96_RS02180	450634..452829	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15635.96 Da
• Isoelectric Point: 10.4623

>T145127 WP_002061280.1 NZ_CP046898:447558-447947 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T145127 NZ_CP062318:120596-120748 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT145127 WP_011860336.1 NZ_CP046898:447306-447551 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT145127 NZ_CP062318:119972-120571 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A7Z1WP95