Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3029831..3030378 Replicon chromosome
Accession NZ_CP046874
Organism Pseudomonas mediterranea strain S58

Toxin (Protein)


Gene name relE Uniprot ID A0A6I6QH28
Locus tag E3Z27_RS13225 Protein ID WP_047698598.1
Coordinates 3030103..3030378 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6I6QAV0
Locus tag E3Z27_RS13220 Protein ID WP_047698600.1
Coordinates 3029831..3030103 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3Z27_RS13200 3025784..3026455 + 672 WP_041022045.1 Bax inhibitor-1/YccA family protein -
E3Z27_RS13205 3026517..3026954 - 438 WP_047698606.1 Lrp/AsnC family transcriptional regulator -
E3Z27_RS13210 3027088..3027981 + 894 WP_159286157.1 DMT family transporter -
E3Z27_RS13215 3027988..3029613 - 1626 WP_047698602.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
E3Z27_RS13220 3029831..3030103 + 273 WP_047698600.1 ribbon-helix-helix domain-containing protein Antitoxin
E3Z27_RS13225 3030103..3030378 + 276 WP_047698598.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3Z27_RS13230 3030599..3031504 - 906 WP_159285624.1 autotransporter outer membrane beta-barrel domain-containing protein -
E3Z27_RS13235 3031805..3034228 - 2424 WP_047698595.1 autotransporter outer membrane beta-barrel domain-containing protein -
E3Z27_RS13240 3034409..3035209 - 801 WP_047698594.1 endonuclease/exonuclease/phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10715.26 Da        Isoelectric Point: 8.5042

>T145124 WP_047698598.1 NZ_CP046874:3030103-3030378 [Pseudomonas mediterranea]
MELKWTSKALSDLARLYEFLAAVNQPAAARTVQQLTAAPTTLLDNPRIGERLEEFEPRDVRRIQIGHYEMRYEVVSSTLY
LLRLWHTRENR

Download         Length: 276 bp

>T145124 NZ_CP062314:2765494-2765703 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10128.52 Da        Isoelectric Point: 5.6994

>AT145124 WP_047698600.1 NZ_CP046874:3029831-3030103 [Pseudomonas mediterranea]
MAIPTKTRSVTAHVPVQLAEKVDLMAERLERSKNWIVKQALSAWIDQEEERSRLTREALADVDAGRVIDHQAIQAWADSL
STDTPLPVPR

Download         Length: 273 bp

>AT145124 NZ_CP062314:2765189-2765482 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I6QH28

Antitoxin

Source ID Structure
AlphaFold DB A0A6I6QAV0

References