Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2395940..2396459 Replicon chromosome
Accession NZ_CP046874
Organism Pseudomonas mediterranea strain S58

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag E3Z27_RS10610 Protein ID WP_081993349.1
Coordinates 2396178..2396459 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J2Y714
Locus tag E3Z27_RS10605 Protein ID WP_003182829.1
Coordinates 2395940..2396188 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3Z27_RS10590 2392362..2393366 + 1005 WP_159285423.1 AAA family ATPase -
E3Z27_RS10595 2393369..2394031 + 663 WP_174245338.1 VWA domain-containing protein -
E3Z27_RS10600 2394223..2395871 + 1649 Protein_2093 phospholipase -
E3Z27_RS10605 2395940..2396188 + 249 WP_003182829.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3Z27_RS10610 2396178..2396459 + 282 WP_081993349.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3Z27_RS10615 2396802..2397650 + 849 WP_047703617.1 transporter substrate-binding domain-containing protein -
E3Z27_RS10620 2397705..2398367 + 663 WP_041024414.1 amino acid ABC transporter permease -
E3Z27_RS10625 2398377..2399039 + 663 WP_047703616.1 amino acid ABC transporter permease -
E3Z27_RS10630 2399036..2399827 + 792 WP_024781239.1 amino acid ABC transporter ATP-binding protein -
E3Z27_RS10635 2399852..2400238 + 387 WP_024781238.1 RidA family protein -
E3Z27_RS10640 2400373..2401138 + 766 Protein_2101 IclR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10920.65 Da        Isoelectric Point: 9.9160

>T145123 WP_081993349.1 NZ_CP046874:2396178-2396459 [Pseudomonas mediterranea]
MTYELEFSDKAWKEWQKLGATLREQFKKQLEERLLNPHVQADRLHGLGCAYKIKLRNAGYRLVYRVVDEVLVVTVIAVGK
RERGQVYDEAAKR

Download         Length: 282 bp

>T145123 NZ_CP062314:2708230-2708334 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9009.43 Da        Isoelectric Point: 4.4000

>AT145123 WP_003182829.1 NZ_CP046874:2395940-2396188 [Pseudomonas mediterranea]
MTHIVLSQVVASISELKKNPMGTVAAGGGLSVAILNRNEPAFYCVPAKEYEAMMDRLEDMELVALCRERENDPTIKVSLD
DL

Download         Length: 249 bp

>AT145123 NZ_CP062314:c2708493-2708329 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB J2Y714

References