Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 301548..302224 Replicon chromosome
Accession NZ_CP046874
Organism Pseudomonas mediterranea strain S58

Toxin (Protein)


Gene name hicA Uniprot ID A0A6I6QGT7
Locus tag E3Z27_RS01280 Protein ID WP_047699956.1
Coordinates 301548..301730 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A6I6Q5Q0
Locus tag E3Z27_RS01285 Protein ID WP_047700163.1
Coordinates 301823..302224 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3Z27_RS01265 297695..299656 + 1962 WP_174245324.1 choline transporter BetT -
E3Z27_RS01270 299668..300409 - 742 Protein_246 SDR family oxidoreductase -
E3Z27_RS01275 300527..301417 + 891 WP_159284785.1 LysR family transcriptional regulator -
E3Z27_RS01280 301548..301730 + 183 WP_047699956.1 type II toxin-antitoxin system HicA family toxin Toxin
E3Z27_RS01285 301823..302224 + 402 WP_047700163.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E3Z27_RS01290 302287..303324 + 1038 WP_055128597.1 L-glyceraldehyde 3-phosphate reductase -
E3Z27_RS01295 303451..304293 - 843 WP_055128598.1 taurine dioxygenase -
E3Z27_RS01300 304342..305181 - 840 WP_159284787.1 taurine ABC transporter permease TauC -
E3Z27_RS01305 305178..305972 - 795 WP_047699950.1 taurine ABC transporter ATP-binding subunit -
E3Z27_RS01310 306001..306978 - 978 WP_055134508.1 taurine ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6897.99 Da        Isoelectric Point: 10.7459

>T145121 WP_047699956.1 NZ_CP046874:301548-301730 [Pseudomonas mediterranea]
MRSREMIRKIEEDGWYLVAVKGSHHQYKHSVKTGRVTIKHPDSDLPRGTINSILKQAGLK

Download         Length: 183 bp

>T145121 NZ_CP062314:2416710-2416817 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14710.45 Da        Isoelectric Point: 4.5232

>AT145121 WP_047700163.1 NZ_CP046874:301823-302224 [Pseudomonas mediterranea]
MKFPVVLHKDADSEYGVTVPDVPGCFSAGSTVAQAFENVKEALSLHYEGLVADGEPLPQIHEVDDHLDNPEYAGGIWGVV
EFDVTPYFGKSVRFNATLPEQLLERIDQTVRKDQRYRSRSGFLAAAALRELST

Download         Length: 402 bp

>AT145121 NZ_CP062314:c2416894-2416834 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I6QGT7

Antitoxin

Source ID Structure
AlphaFold DB A0A6I6Q5Q0

References