Detailed information of TA system TA145109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1016226..1016791
• Replicon: chromosome
• Accession: NZ_CP046849
• Organism: Vibrio cincinnatiensis strain F8054

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPX94_RS17600
• Protein ID: WP_154116254.1
• Coordinates: 1016504..1016791 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W9USL4
• Locus tag: GPX94_RS17595
• Protein ID: WP_000086650.1
• Coordinates: 1016226..1016507 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX94_RS17560	1011622..1012014	+	393	WP_154116397.1	nuclear transport factor 2 family protein	-
GPX94_RS17565	1013131..1013421	+	291	WP_154116395.1	hypothetical protein	-
GPX94_RS17570	1013477..1013587	+	111	WP_154116918.1	DUF3265 domain-containing protein	-
GPX94_RS17575	1013626..1014018	+	393	WP_154116282.1	nuclear transport factor 2 family protein	-
GPX94_RS17580	1014129..1014806	+	678	WP_154116393.1	FMN-binding negative transcriptional regulator	-
GPX94_RS17585	1014812..1014925	+	114	WP_154116922.1	DUF3265 domain-containing protein	-
GPX94_RS17590	1015472..1016026	+	555	WP_154116391.1	hypothetical protein	-
GPX94_RS17595	1016226..1016507	+	282	WP_000086650.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPX94_RS17600	1016504..1016791	+	288	WP_154116254.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPX94_RS17605	1016801..1016911	+	111	WP_154116889.1	DUF3265 domain-containing protein	-
GPX94_RS17610	1017458..1017874	+	417	WP_154116389.1	VOC family protein	-
GPX94_RS17615	1018016..1018645	+	630	WP_154116387.1	FMN-binding negative transcriptional regulator	-
GPX94_RS17620	1018651..1018764	+	114	WP_154116922.1	DUF3265 domain-containing protein	-
GPX94_RS17625	1019261..1019527	+	267	WP_154116385.1	hypothetical protein	-
GPX94_RS17630	1019840..1021027	+	1188	WP_154116383.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	cqsA / katB	1..1034285	1034284
	-	inside	Integron	-	-	972405..1019527	47122

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10943.74 Da
• Isoelectric Point: 5.6096

>T145109 WP_154116254.1 NZ_CP046849:1016504-1016791 [Vibrio cincinnatiensis]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELIGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLGLEIRV
LTVRNCRQLLTEHDV

Nucleotide

• Length: 288 bp

>T145109 NZ_CP062312:c1236394-1236077 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10347.90 Da
• Isoelectric Point: 5.1548

>AT145109 WP_000086650.1 NZ_CP046849:1016226-1016507 [Vibrio cincinnatiensis]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK

Nucleotide

• Length: 282 bp

>AT145109 NZ_CP062312:c1236606-1236397 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATAGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: W9USL4