Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 984939..985477 Replicon chromosome
Accession NZ_CP046849
Organism Vibrio cincinnatiensis strain F8054

Toxin (Protein)


Gene name parE Uniprot ID A0A0N8UHD2
Locus tag GPX94_RS17355 Protein ID WP_000802131.1
Coordinates 984939..985238 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0Q0JMN6
Locus tag GPX94_RS17360 Protein ID WP_002044787.1
Coordinates 985235..985477 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX94_RS17335 979950..980354 + 405 WP_154116443.1 hypothetical protein -
GPX94_RS17340 980347..981540 + 1194 WP_154116441.1 hypothetical protein -
GPX94_RS17345 983254..983757 + 504 WP_000734953.1 hypothetical protein -
GPX94_RS17350 983910..984302 + 393 WP_154116282.1 nuclear transport factor 2 family protein -
GPX94_RS17355 984939..985238 - 300 WP_000802131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPX94_RS17360 985235..985477 - 243 WP_002044787.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GPX94_RS17365 985772..986143 + 372 WP_154116929.1 CPBP family intramembrane metalloprotease -
GPX94_RS17370 986418..986678 + 261 WP_154116439.1 DUF3709 domain-containing protein -
GPX94_RS17375 987023..987421 + 399 WP_078927613.1 aegerolysin family protein -
GPX94_RS17380 987484..987600 + 117 WP_154116927.1 DUF3265 domain-containing protein -
GPX94_RS17385 988680..988901 + 222 Protein_899 transposase -
GPX94_RS17390 988985..989836 + 852 WP_158147654.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / katB 1..1034285 1034284
- inside Integron - - 972405..1019527 47122
- flank IS/Tn - - 990277..991233 956


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11607.26 Da        Isoelectric Point: 9.9232

>T145108 WP_000802131.1 NZ_CP046849:c985238-984939 [Vibrio cincinnatiensis]
MKPFNLTTAAKTDLRDIALFTQRRWGKEQRNIYLKQFDDSFWLLAENPDIGKSCDEIRDGYRKFPQGSHVIFYQQTGSQQ
IRVVRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145108 NZ_CP062312:1209460-1209648 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8979.81 Da        Isoelectric Point: 4.1677

>AT145108 WP_002044787.1 NZ_CP046849:c985477-985235 [Vibrio cincinnatiensis]
MAKNTSITLGEHFDGFITNQIQSGRYGSASEVIRSALRLLENQETKLQTLRQLLVEGEQSGDADYDLDSFINELDSETNR

Download         Length: 243 bp

>AT145108 NZ_CP062312:1209171-1209431 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N8UHD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0JMN6

References