Detailed information of TA system TA145107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 950620..951160
• Replicon: chromosome
• Accession: NZ_CP046849
• Organism: Vibrio cincinnatiensis strain F8054

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPX94_RS17165
• Protein ID: WP_158147745.1
• Coordinates: 950620..950889 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1T4SKS5
• Locus tag: GPX94_RS17170
• Protein ID: WP_032480862.1
• Coordinates: 950882..951160 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX94_RS17115	945698..946660	-	963	WP_078925954.1	integron integrase	-
GPX94_RS17120	947462..947743	+	282	WP_000086650.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GPX94_RS17125	947740..948027	+	288	WP_154116254.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GPX94_RS17130	948037..948147	+	111	WP_154116889.1	DUF3265 domain-containing protein	-
GPX94_RS17135	948137..948388	+	252	WP_199251712.1	acetyltransferase	-
GPX94_RS17140	948388..948789	+	402	WP_000351249.1	type II toxin-antitoxin system death-on-curing family toxin	-
GPX94_RS17145	948951..949376	+	426	WP_158147742.1	N-acetyltransferase	-
GPX94_RS17150	949405..949494	+	90	WP_158147743.1	hypothetical protein	-
GPX94_RS17155	949523..949981	+	459	WP_158147744.1	hypothetical protein	-
GPX94_RS17160	950482..950592	+	111	WP_129533207.1	DUF3265 domain-containing protein	-
GPX94_RS17165	950620..950889	-	270	WP_158147745.1	type II toxin-antitoxin system YafQ family toxin	Toxin
GPX94_RS17170	950882..951160	-	279	WP_032480862.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GPX94_RS17175	951217..951327	+	111	WP_158137443.1	DUF3265 domain-containing protein	-
GPX94_RS17180	951411..952124	+	714	WP_176429172.1	Fic family protein	-
GPX94_RS17185	952121..952231	+	111	Protein_861	DUF3265 domain-containing protein	-
GPX94_RS17195	952812..952922	+	111	WP_158145475.1	DUF3265 domain-containing protein	-
GPX94_RS17200	952961..953530	+	570	WP_158147746.1	flavodoxin family protein	-
GPX94_RS17205	954960..955517	+	558	WP_158145089.1	hypothetical protein	-
GPX94_RS17210	955524..955634	+	111	WP_158145473.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	cqsA / katB	1..1034285	1034284
	-	inside	Integron	-	-	945698..969207	23509

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10236.89 Da
• Isoelectric Point: 8.9357

>T145107 WP_158147745.1 NZ_CP046849:c950889-950620 [Vibrio cincinnatiensis]
MYSLEYSSQFKKDFKKITKMPISDIIEVGNIISKLQRGEKLDPKNVDHPLTGGWVGFRDCHVKPDLVLIYRIFDGQLQLA
RIGSHSDLF

Nucleotide

• Length: 270 bp

>T145107 NZ_CP062312:c181048-180953 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10053.51 Da
• Isoelectric Point: 6.0643

>AT145107 WP_032480862.1 NZ_CP046849:c951160-950882 [Vibrio cincinnatiensis]
MRTEMLSTRIDHDTKVAFTSICDEMGLSTSQAIKIFAKAVINHGGIPFDLRVPQPNETTISAMNELVQGHGHKAESVDAM
LTELTEGKVKNV

Nucleotide

• Length: 279 bp

>AT145107 NZ_CP062312:180868-180925 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin

• AlphaFold DB: A0A1T4SKS5