Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc(toxin) |
| Location | 948137..948789 | Replicon | chromosome |
| Accession | NZ_CP046849 | ||
| Organism | Vibrio cincinnatiensis strain F8054 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A1T4SJW3 |
| Locus tag | GPX94_RS17140 | Protein ID | WP_000351249.1 |
| Coordinates | 948388..948789 (+) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | - |
| Locus tag | GPX94_RS17135 | Protein ID | WP_199251712.1 |
| Coordinates | 948137..948388 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPX94_RS17100 | 944411..944962 | + | 552 | WP_099610045.1 | translation initiation factor IF-3 | - |
| GPX94_RS17105 | 945062..945256 | + | 195 | WP_004727973.1 | 50S ribosomal protein L35 | - |
| GPX94_RS17110 | 945298..945651 | + | 354 | WP_040992521.1 | 50S ribosomal protein L20 | - |
| GPX94_RS17115 | 945698..946660 | - | 963 | WP_078925954.1 | integron integrase | - |
| GPX94_RS17120 | 947462..947743 | + | 282 | WP_000086650.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPX94_RS17125 | 947740..948027 | + | 288 | WP_154116254.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPX94_RS17130 | 948037..948147 | + | 111 | WP_154116889.1 | DUF3265 domain-containing protein | - |
| GPX94_RS17135 | 948137..948388 | + | 252 | WP_199251712.1 | acetyltransferase | Antitoxin |
| GPX94_RS17140 | 948388..948789 | + | 402 | WP_000351249.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| GPX94_RS17145 | 948951..949376 | + | 426 | WP_158147742.1 | N-acetyltransferase | - |
| GPX94_RS17150 | 949405..949494 | + | 90 | WP_158147743.1 | hypothetical protein | - |
| GPX94_RS17155 | 949523..949981 | + | 459 | WP_158147744.1 | hypothetical protein | - |
| GPX94_RS17160 | 950482..950592 | + | 111 | WP_129533207.1 | DUF3265 domain-containing protein | - |
| GPX94_RS17165 | 950620..950889 | - | 270 | WP_158147745.1 | type II toxin-antitoxin system YafQ family toxin | - |
| GPX94_RS17170 | 950882..951160 | - | 279 | WP_032480862.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| GPX94_RS17175 | 951217..951327 | + | 111 | WP_158137443.1 | DUF3265 domain-containing protein | - |
| GPX94_RS17180 | 951411..952124 | + | 714 | WP_176429172.1 | Fic family protein | - |
| GPX94_RS17185 | 952121..952231 | + | 111 | Protein_861 | DUF3265 domain-containing protein | - |
| GPX94_RS17195 | 952812..952922 | + | 111 | WP_158145475.1 | DUF3265 domain-containing protein | - |
| GPX94_RS17200 | 952961..953530 | + | 570 | WP_158147746.1 | flavodoxin family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / katB | 1..1034285 | 1034284 | |
| - | inside | Integron | - | - | 945698..969207 | 23509 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14636.77 Da Isoelectric Point: 4.0128
>T145106 WP_000351249.1 NZ_CP046849:948388-948789 [Vibrio cincinnatiensis]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSVL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSVL
Download Length: 402 bp
>T145106 NZ_CP062312:120647-120799 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGACTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGACTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9355.07 Da Isoelectric Point: 10.6487
>AT145106 WP_199251712.1 NZ_CP046849:948137-948388 [Vibrio cincinnatiensis]
MPLKRALCFLLRFGAIIGQTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKL
ADM
MPLKRALCFLLRFGAIIGQTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKL
ADM
Download Length: 252 bp
>AT145106 NZ_CP062312:120023-120622 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|