Detailed information of TA system TA145105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-phd/ParE(toxin)
• Location: 947740..948388
• Replicon: chromosome
• Accession: NZ_CP046849
• Organism: Vibrio cincinnatiensis strain F8054

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPX94_RS17125
• Protein ID: WP_154116254.1
• Coordinates: 947740..948027 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: GPX94_RS17135
• Protein ID: WP_199251712.1
• Coordinates: 948137..948388 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX94_RS17100	944411..944962	+	552	WP_099610045.1	translation initiation factor IF-3	-
GPX94_RS17105	945062..945256	+	195	WP_004727973.1	50S ribosomal protein L35	-
GPX94_RS17110	945298..945651	+	354	WP_040992521.1	50S ribosomal protein L20	-
GPX94_RS17115	945698..946660	-	963	WP_078925954.1	integron integrase	-
GPX94_RS17120	947462..947743	+	282	WP_000086650.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GPX94_RS17125	947740..948027	+	288	WP_154116254.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPX94_RS17130	948037..948147	+	111	WP_154116889.1	DUF3265 domain-containing protein	-
GPX94_RS17135	948137..948388	+	252	WP_199251712.1	acetyltransferase	Antitoxin
GPX94_RS17140	948388..948789	+	402	WP_000351249.1	type II toxin-antitoxin system death-on-curing family toxin	-
GPX94_RS17145	948951..949376	+	426	WP_158147742.1	N-acetyltransferase	-
GPX94_RS17150	949405..949494	+	90	WP_158147743.1	hypothetical protein	-
GPX94_RS17155	949523..949981	+	459	WP_158147744.1	hypothetical protein	-
GPX94_RS17160	950482..950592	+	111	WP_129533207.1	DUF3265 domain-containing protein	-
GPX94_RS17165	950620..950889	-	270	WP_158147745.1	type II toxin-antitoxin system YafQ family toxin	-
GPX94_RS17170	950882..951160	-	279	WP_032480862.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
GPX94_RS17175	951217..951327	+	111	WP_158137443.1	DUF3265 domain-containing protein	-
GPX94_RS17180	951411..952124	+	714	WP_176429172.1	Fic family protein	-
GPX94_RS17185	952121..952231	+	111	Protein_861	DUF3265 domain-containing protein	-
GPX94_RS17195	952812..952922	+	111	WP_158145475.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	cqsA / katB	1..1034285	1034284
	-	inside	Integron	-	-	945698..969207	23509

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10943.74 Da
• Isoelectric Point: 5.6096

>T145105 WP_154116254.1 NZ_CP046849:947740-948027 [Vibrio cincinnatiensis]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELIGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLGLEIRV
LTVRNCRQLLTEHDV

Nucleotide

• Length: 288 bp

>T145105 NZ_CP062312:19314-19490 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9355.07 Da
• Isoelectric Point: 10.6487

>AT145105 WP_199251712.1 NZ_CP046849:948137-948388 [Vibrio cincinnatiensis]
MPLKRALCFLLRFGAIIGQTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKL
ADM

Nucleotide

• Length: 252 bp

>AT145105 NZ_CP062312:c19652-19478 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG