Detailed information of TA system TA145103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 114101..114648
• Replicon: chromosome
• Accession: NZ_CP046849
• Organism: Vibrio cincinnatiensis strain F8054

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A223N2K4
• Locus tag: GPX94_RS13675
• Protein ID: WP_000229324.1
• Coordinates: 114346..114648 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: GPX94_RS13670
• Protein ID: WP_000861987.1
• Coordinates: 114101..114358 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX94_RS13625	109406..109627	+	222	Protein_150	transposase	-
GPX94_RS13630	109711..110562	+	852	WP_158147655.1	IS3 family transposase	-
GPX94_RS13635	110649..111263	+	615	WP_154116229.1	outer membrane beta-barrel protein	-
GPX94_RS13640	111417..111881	+	465	WP_154116228.1	ASCH domain-containing protein	-
GPX94_RS13645	111882..111995	+	114	Protein_154	DUF3265 domain-containing protein	-
GPX94_RS13650	112024..112653	+	630	WP_154116226.1	FMN-binding negative transcriptional regulator	-
GPX94_RS13655	112802..113080	-	279	WP_045569735.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
GPX94_RS13660	113077..113361	-	285	WP_154116224.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
GPX94_RS13665	113417..113527	+	111	Protein_158	DUF3265 domain-containing protein	-
GPX94_RS13670	114101..114358	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPX94_RS13675	114346..114648	+	303	WP_000229324.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPX94_RS13680	114658..114774	+	117	Protein_161	DUF3265 domain-containing protein	-
GPX94_RS13685	115474..116799	+	1326	WP_115173883.1	group II intron reverse transcriptase/maturase	-
GPX94_RS13690	117033..118085	+	1053	WP_195707330.1	ISAs1 family transposase	-
GPX94_RS13695	118123..118704	+	582	WP_154116222.1	DUF1287 domain-containing protein	-
GPX94_RS13700	118780..119607	-	828	WP_154116220.1	sulfurtransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	cqsA / katB	1..1034285	1034284
	-	inside	Integron	-	-	93986..114358	20372

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11795.70 Da
• Isoelectric Point: 4.9166

>T145103 WP_000229324.1 NZ_CP046849:114346-114648 [Vibrio cincinnatiensis]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDEKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T145103 NZ_CP062271:7923-8180 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT145103 WP_000861987.1 NZ_CP046849:114101-114358 [Vibrio cincinnatiensis]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT145103 NZ_CP062271:7661-7930 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Structures

Toxin

• AlphaFold DB: A0A223N2K4

Antitoxin

• AlphaFold DB: A0A1T4SLM9