Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 107630..108396 Replicon chromosome
Accession NZ_CP046849
Organism Vibrio cincinnatiensis strain F8054

Toxin (Protein)


Gene name - Uniprot ID A0A6G3L8F0
Locus tag GPX94_RS13605 Protein ID WP_010319335.1
Coordinates 107630..108127 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID C9P137
Locus tag GPX94_RS13610 Protein ID WP_004394087.1
Coordinates 108124..108396 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX94_RS13570 102644..102733 + 90 WP_154116241.1 hypothetical protein -
GPX94_RS13575 102871..103506 + 636 WP_154116239.1 hypothetical protein -
GPX94_RS13580 103811..103942 + 132 WP_154116883.1 DUF3265 domain-containing protein -
GPX94_RS13585 104074..104259 + 186 WP_154116238.1 hypothetical protein -
GPX94_RS13590 104256..105380 - 1125 WP_154116235.1 ISAs1 family transposase -
GPX94_RS13595 105565..106413 + 849 WP_154116233.1 lipase family protein -
GPX94_RS13600 106524..106646 + 123 Protein_145 DUF3265 domain-containing protein -
GPX94_RS13605 107630..108127 - 498 WP_010319335.1 GNAT family N-acetyltransferase Toxin
GPX94_RS13610 108124..108396 - 273 WP_004394087.1 DUF1778 domain-containing protein Antitoxin
GPX94_RS13615 108436..108597 + 162 WP_154116881.1 DUF3265 domain-containing protein -
GPX94_RS13620 108632..109246 + 615 WP_154116231.1 hypothetical protein -
GPX94_RS13625 109406..109627 + 222 Protein_150 transposase -
GPX94_RS13630 109711..110562 + 852 WP_158147655.1 IS3 family transposase -
GPX94_RS13635 110649..111263 + 615 WP_154116229.1 outer membrane beta-barrel protein -
GPX94_RS13640 111417..111881 + 465 WP_154116228.1 ASCH domain-containing protein -
GPX94_RS13645 111882..111995 + 114 Protein_154 DUF3265 domain-containing protein -
GPX94_RS13650 112024..112653 + 630 WP_154116226.1 FMN-binding negative transcriptional regulator -
GPX94_RS13655 112802..113080 - 279 WP_045569735.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GPX94_RS13660 113077..113361 - 285 WP_154116224.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / katB 1..1034285 1034284
- inside Integron - - 93986..114358 20372


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18577.41 Da        Isoelectric Point: 9.5688

>T145101 WP_010319335.1 NZ_CP046849:c108127-107630 [Vibrio cincinnatiensis]
MMKTVLLDKDKHDRNRFNCGIDALNNYLKVMASQQAKKDNTRTFVLEDENNTSLIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAIDERYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFKAFQDAENKLFITISDI
RASLG

Download         Length: 498 bp

>T145101 NZ_CP062268:c10202-9852 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9872.43 Da        Isoelectric Point: 9.7681

>AT145101 WP_004394087.1 NZ_CP046849:c108396-108124 [Vibrio cincinnatiensis]
MATTLPRITARVDVDTQNLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQTLKLSQADAILLMEALDKPTTLNQKLKT
AAERYETKNQ

Download         Length: 273 bp

>AT145101 NZ_CP062268:c10459-10196 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G3L8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SI33

References