Detailed information of TA system TA145100

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 95570..96135
• Replicon: chromosome
• Accession: NZ_CP046849
• Organism: Vibrio cincinnatiensis strain F8054

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPX94_RS13500
• Protein ID: WP_154116254.1
• Coordinates: 95848..96135 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GPX94_RS13495
• Protein ID: WP_195707331.1
• Coordinates: 95570..95851 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX94_RS13480	91374..93107	-	1734	WP_154116260.1	DUF262 domain-containing HNH endonuclease family protein	-
GPX94_RS13485	94128..94598	+	471	WP_158147665.1	N-acetyltransferase	-
GPX94_RS13490	94735..95352	+	618	WP_154116258.1	HAD family phosphatase	-
GPX94_RS13495	95570..95851	+	282	WP_195707331.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPX94_RS13500	95848..96135	+	288	WP_154116254.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPX94_RS13505	96145..96255	+	111	WP_154116889.1	DUF3265 domain-containing protein	-
GPX94_RS13510	96337..96558	+	222	Protein_127	transposase	-
GPX94_RS13515	96642..97493	+	852	WP_158147666.1	IS3 family transposase	-
GPX94_RS13520	97558..97863	+	306	WP_199251709.1	hypothetical protein	-
GPX94_RS13525	97841..97990	+	150	WP_154116887.1	DUF3265 domain-containing protein	-
GPX94_RS13530	98518..99444	+	927	WP_158147667.1	PD-(D/E)XK nuclease superfamily protein	-
GPX94_RS13535	99676..99924	+	249	WP_154116250.1	DUF3297 family protein	-
GPX94_RS13540	100026..100140	+	115	Protein_133	hypothetical protein	-
GPX94_RS13545	100196..100543	+	348	WP_154116248.1	DUF3024 domain-containing protein	-
GPX94_RS13550	100543..100668	+	126	WP_154116885.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	cqsA / katB	1..1034285	1034284
	-	inside	Integron	-	-	93986..114358	20372

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10943.74 Da
• Isoelectric Point: 5.6096

>T145100 WP_154116254.1 NZ_CP046849:95848-96135 [Vibrio cincinnatiensis]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELIGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLGLEIRV
LTVRNCRQLLTEHDV

Nucleotide

• Length: 288 bp

>T145100 NZ_CP062266:c214056-213784 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10381.92 Da
• Isoelectric Point: 5.1548

>AT145100 WP_195707331.1 NZ_CP046849:95570-95851 [Vibrio cincinnatiensis]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGFGVSN
EDARSQVLGRIIK

Nucleotide

• Length: 282 bp

>AT145100 NZ_CP062266:c214319-214056 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA