Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 44455..45017 Replicon chromosome
Accession NZ_CP046849
Organism Vibrio cincinnatiensis strain F8054

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag GPX94_RS13205 Protein ID WP_154116302.1
Coordinates 44455..44772 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag GPX94_RS13210 Protein ID WP_099609954.1
Coordinates 44772..45017 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX94_RS13175 40322..41446 + 1125 WP_154116312.1 ISAs1 family transposase -
GPX94_RS13180 41518..41982 + 465 WP_154116310.1 hypothetical protein -
GPX94_RS13185 42114..42548 + 435 WP_154116308.1 hypothetical protein -
GPX94_RS13190 42739..42960 + 222 Protein_62 transposase -
GPX94_RS13195 43044..43895 + 852 WP_158147655.1 IS3 family transposase -
GPX94_RS13200 43944..44378 + 435 WP_154116304.1 GNAT family N-acetyltransferase -
GPX94_RS13205 44455..44772 - 318 WP_154116302.1 CcdB family protein Toxin
GPX94_RS13210 44772..45017 - 246 WP_099609954.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
GPX94_RS13215 45073..45183 + 111 Protein_67 DUF3265 domain-containing protein -
GPX94_RS13220 45265..45486 + 222 Protein_68 transposase -
GPX94_RS13225 45570..46421 + 852 WP_158147656.1 IS3 family transposase -
GPX94_RS13230 46494..47117 + 624 WP_064626866.1 DUF1349 domain-containing protein -
GPX94_RS13235 47286..48284 + 999 WP_154116298.1 alpha/beta fold hydrolase -
GPX94_RS13240 48436..48822 + 387 WP_154116296.1 VOC family protein -
GPX94_RS17745 49007..49576 + 570 WP_199251705.1 SEC-C domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / katB 1..1034285 1034284


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(3-104)

Antitoxin

Post-segregation antitoxin CcdA

(11-81)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11842.64 Da        Isoelectric Point: 4.6966

>T145099 WP_154116302.1 NZ_CP046849:c44772-44455 [Vibrio cincinnatiensis]
MSQFSLYQNNDKSTSTAYPYFVDVQSELLDTLNTRLVIPLTPVELLDKKAPNHLCPVIHIDQGDFVILTHQMASVPTKIL
REPVNELSTFRNEIIAAIDFLITGI

Download         Length: 318 bp

>T145099 NZ_CP062266:18472-18729 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9259.45 Da        Isoelectric Point: 6.9792

>AT145099 WP_099609954.1 NZ_CP046849:c45017-44772 [Vibrio cincinnatiensis]
MRNSYSTQAPKKATNLTLNSELLAEAKRLNINLSATMEKALEKEVKQRLKTEWLEQNAEAINACNELTENHGLFSDSYRV
F

Download         Length: 246 bp

>AT145099 NZ_CP062266:18210-18479 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References