Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 37047..37618 Replicon chromosome
Accession NZ_CP046849
Organism Vibrio cincinnatiensis strain F8054

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag GPX94_RS13150 Protein ID WP_000351248.1
Coordinates 37217..37618 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag GPX94_RS13145 Protein ID WP_001080654.1
Coordinates 37047..37217 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX94_RS17740 32088..33044 - 957 WP_195707319.1 IS110 family transposase -
GPX94_RS13125 34496..34891 + 396 WP_154116906.1 hypothetical protein -
GPX94_RS13130 34888..35004 + 117 Protein_50 DUF3265 domain-containing protein -
GPX94_RS13135 35051..35410 + 360 WP_154116316.1 hypothetical protein -
GPX94_RS13140 35560..36867 + 1308 WP_154116314.1 DUF3644 domain-containing protein -
GPX94_RS13145 37047..37217 + 171 WP_001080654.1 hypothetical protein Antitoxin
GPX94_RS13150 37217..37618 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GPX94_RS13155 37588..37731 + 144 WP_195707336.1 DUF3265 domain-containing protein -
GPX94_RS13160 37799..38131 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPX94_RS13165 38118..38432 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
GPX94_RS13170 39219..39515 + 297 WP_053339486.1 PQQ-binding-like beta-propeller repeat protein -
GPX94_RS13175 40322..41446 + 1125 WP_154116312.1 ISAs1 family transposase -
GPX94_RS13180 41518..41982 + 465 WP_154116310.1 hypothetical protein -
GPX94_RS13185 42114..42548 + 435 WP_154116308.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / katB 1..1034285 1034284
- flank IS/Tn - - 32088..33044 956


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T145097 WP_000351248.1 NZ_CP046849:37217-37618 [Vibrio cincinnatiensis]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T145097 NZ_CP062265:1478691-1478957 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT145097 WP_001080654.1 NZ_CP046849:37047-37217 [Vibrio cincinnatiensis]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT145097 NZ_CP062265:1478428-1478691 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References